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Table 2 Eighteen mRNAsa with greatest pleiotropy across metabolic traits using a cut-off of FDR <0.001 to define significance of association

From: Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors

Gene Symbol Gene Name # Traits at FDR < 0.001 Traits Associated
FAM13A family with sequence similarity 13, member A 6 All
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity 6 All
HIST1H2AC histone cluster 1, H2ac 6 All
WNK1 WNK lysine deficient protein kinase 1 6 All
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 5 All but glucose
LSP1 lymphocyte-specific protein 1 5 All but glucose
LMBRD1 LMBR1 domain containing 1 5 All but SBP
ZNF721 zinc finger protein 721 5 All but SBP
PARP15 poly (ADP-ribose) polymerase family, member 15 5 All but glucose
ZNF644 zinc finger protein 644 5 All but SBP
AP2B1 adaptor-related protein complex 2, beta 1 subunit 5 All but SBP
PDS5B PDS5, regulator of cohesion maintenance, homolog B 5 All but glucose
HIST1H4E histone cluster 1, H4e 5 All but HDL-C
ZNF267 zinc finger protein 267 5 All but HDL-C
SAMHD1 SAM domain and HD domain 1 5 All but HDL-C
CAPN2 calpain 2, (m/II) large subunit 5 All but HDL-C
KLF10 Kruppel-like factor 10 5 All but HDL-C
CAST calpastatin 5 All but HDL-C
  1. aEighteen mRNAs represent all mRNAs associated with five or more cardiometabolic traits