Fig. 3

Analysis of differentially expressed genes. a The comparison of up-regulated and down-regulated genes from sequencing and microarray analysis during additional molar morphogenesis showing that up-regulated genes (red) are predominant at E60 versus E50, while down-regulated genes (green) are dominant at E70 versus E60. b Venn diagram analysis for differential expression genes from sequencing and microarray during additional molar morphogenesis showing more changes in gene expression at E60 versus E50 and relatively fewer changes between E70 and E60. c Pathway enrichment from microarray and sequencing between two stages showing that the WNT, TGF-β and MAPK pathways may be involved in cascade initiation of additional molars