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Table 1 Results of locality analysis of genes with changing transcript levels over time

From: An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo

Gene Symbol Gene Name Locality Correlation Gene/Age Diff. Analysis Old/young
Score p r p log2 (FC) adj.p
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.25 1E-04 −0.33 0.026 −0.26 0.006
ODC1 ornithine decarboxylase 1 0.26 2E-04 −0.26 0.076 −0.30 0.085
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.22 4E-04 0.38 0.01 0.30 0.112
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.31 7E-04 0.55 7E-05 0.45 7E-05
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.21 0.002 0.34 0.022 0.18 0.026
ALDOA aldolase A, fructose-bisphosphate 0.24 0.003 0.57 3E-05 0.24 0.002
TARS threonyl-tRNA synthetase 0.29 0.003 −0.54 1E-04 −0.75 6E-06
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 0.28 0.006 −0.39 0.007 −0.27 0.011
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.19 0.008 −0.40 0.005 −0.20 0.012
ALAD aminolevulinate dehydratase 0.24 0.008 0.19 0.204 0.22 0.061
IL4I1 interleukin 4 induced 1 0.21 0.014 −0.16 0.297 −0.58 0.052
FBP1 fructose-1,6-bisphosphatase 1 0.27 0.016 0.34 0.022 0.22 0.094
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.26 0.017 0.37 0.012 0.29 0.019
YARS tyrosyl-tRNA synthetase 0.27 0.02 −0.48 8E-04 −0.54 6E-04
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.28 0.021 −0.35 0.019 −0.39 0.006
PRDX6 peroxiredoxin 6 0.24 0.021 0.36 0.015 0.14 0.056
AGA aspartylglucosaminidase 0.18 0.032 0.25 0.101 0.15 0.077
TST thiosulfate sulfurtransferase (rhodanese) 0.24 0.034 0.31 0.039 0.31 0.041
ACP5 acid phosphatase 5, tartrate resistant 0.26 0.038 0.31 0.036 0.36 0.007
IARS isoleucyl-tRNA synthetase 0.28 0.039 −0.40 0.006 −0.44 0.002
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.22 0.041 0.26 0.077 0.13 0.062
  1. All genes with p < 0.05 for the locality analysis and p < 0.1 for the gene-age correlation or the differential analysis are listed. The full results are summarized in Additional file 6