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Table 1 Results of locality analysis of genes with changing transcript levels over time

From: An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo

Gene Symbol

Gene Name

Locality

Correlation Gene/Age

Diff. Analysis Old/young

Score

p

r

p

log2 (FC)

adj.p

ALDH4A1

aldehyde dehydrogenase 4 family, member A1

0.25

1E-04

−0.33

0.026

−0.26

0.006

ODC1

ornithine decarboxylase 1

0.26

2E-04

−0.26

0.076

−0.30

0.085

GALNT6

polypeptide N-acetylgalactosaminyltransferase 6

0.22

4E-04

0.38

0.01

0.30

0.112

TARS2

threonyl-tRNA synthetase 2, mitochondrial (putative)

0.31

7E-04

0.55

7E-05

0.45

7E-05

BCKDHA

branched chain keto acid dehydrogenase E1, alpha polypeptide

0.21

0.002

0.34

0.022

0.18

0.026

ALDOA

aldolase A, fructose-bisphosphate

0.24

0.003

0.57

3E-05

0.24

0.002

TARS

threonyl-tRNA synthetase

0.29

0.003

−0.54

1E-04

−0.75

6E-06

YARS2

tyrosyl-tRNA synthetase 2, mitochondrial

0.28

0.006

−0.39

0.007

−0.27

0.011

CYP51A1

cytochrome P450, family 51, subfamily A, polypeptide 1

0.19

0.008

−0.40

0.005

−0.20

0.012

ALAD

aminolevulinate dehydratase

0.24

0.008

0.19

0.204

0.22

0.061

IL4I1

interleukin 4 induced 1

0.21

0.014

−0.16

0.297

−0.58

0.052

FBP1

fructose-1,6-bisphosphatase 1

0.27

0.016

0.34

0.022

0.22

0.094

GATM

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

0.26

0.017

0.37

0.012

0.29

0.019

YARS

tyrosyl-tRNA synthetase

0.27

0.02

−0.48

8E-04

−0.54

6E-04

GART

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

0.28

0.021

−0.35

0.019

−0.39

0.006

PRDX6

peroxiredoxin 6

0.24

0.021

0.36

0.015

0.14

0.056

AGA

aspartylglucosaminidase

0.18

0.032

0.25

0.101

0.15

0.077

TST

thiosulfate sulfurtransferase (rhodanese)

0.24

0.034

0.31

0.039

0.31

0.041

ACP5

acid phosphatase 5, tartrate resistant

0.26

0.038

0.31

0.036

0.36

0.007

IARS

isoleucyl-tRNA synthetase

0.28

0.039

−0.40

0.006

−0.44

0.002

NDUFV2

NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa

0.22

0.041

0.26

0.077

0.13

0.062

  1. All genes with p < 0.05 for the locality analysis and p < 0.1 for the gene-age correlation or the differential analysis are listed. The full results are summarized in Additional file 6
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BMC Genomics

ISSN: 1471-2164

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