Fig. 3

Schematic representations of the metabolite and transcript regulation in glycolysis and tricarboxylic acid cycle pathways. Regulated steps in glycolysis (a) and the TCA pathways (b) in response to Akt1-mediated muscle growth are shown. Metabolites with significant changes (from metabolome results) are shown as vertical bar graphs, whereas gene expression changes for enzymes (from RNA-seq results) are shown as horizontal bar graphs. Open column is control (MckrtTA) and filled column is DTG mice. * denotes p-value (for metabolites) or FDR (for transcripts) <0.005, # denotes p-value <0.05), and + denotes p < 0.1