Fig. 6

Increased expression of cell cycle regulators and pro-inflammatory transcripts during Akt1-mediated muscle growth. Transcripts with significant expression changes (fold change ≥ 2-fold, FDR < 0.005 for all transcripts) from RNA-seq results were represented in the histograms. a Increased expression of transcripts encoding for cell cycle regulators in Akt1-mediated muscle growth. b Expression changes of transcripts encoding for chemokines or cytokines in the gastrocnemius muscles of MckrtTA and DTG mice (fold change ≥ 2-fold, FDR < 0.005 for all transcripts listed). c Increased expression of the transcripts encoding for receptors of chemokines/cytokines and inflammatory cell markers (fold change ≥ 2-fold, FDR < 0.005 for all transcripts listed). d Immunohistochemical analysis showing the increased presence of inflammatory cell markers CD68 and F4/80 in gastrocnemius muscle from DTG mice compared to control STG mice