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Fig. 4 | BMC Genomics

Fig. 4

From: House spider genome uncovers evolutionary shifts in the diversity and expression of black widow venom proteins associated with extreme toxicity

Fig. 4

Genomic duplication and inversion of CHH/ITP/latrodectin homologs associated with a shift to venom gland expression. a Locations of house spider latrodectin and crustacean hyperglycemic hormone (CHH) and ion transport peptide (ITP) homologs on genomic scaffold 26. Genes with high expression in venom glands are in orange, and homologs with low venom gland expression in blue; expression indicated by venom gland TPM (b) Bayesian 50% consensus tree of diverse CHH/ITP/latrodectin peptides rooted with C. elegans ITP homologs, with sequences labeled by species and NCBI accession number. Nodes with posterior probability = > 0.95 indicated by gray dots; sequences with high venom gland expressed sequences (venom TPM > 100) labeled with orange squares, those with no or negligible venom gland expression (venom TPM < 2) with blue squares; those from non-venomous animal with yellow squares. Two venom gland ESTs from Loxosceles (recluse) spiders that lack abundance/expression estimates are labeled with purple squares. The five house spider latrodectins/CHH/ITP peptides encoded on genomic scaffold 26 are indicated with asterisks. Hatched lines indicate shortened branch for figure quality. Please see Additional file 9 for a high resolution version of this figure

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