Table 2 Differential gene expression between abdominal and gluteal adipose tissue depots
From: Gene expression regional differences in human subcutaneous adipose tissue
Down-regulated in abdomen vs gluteus | Up-regulate in abdomen vs gluteus | ||||
|---|---|---|---|---|---|
Gene | FC | Description | Gene | FC | Description |
HOXC12 | 45,90 | Homo sapiens homeobox C12 (HOXC12), MRNA [NM_173860] | DMRT3 | 13,75 | Homo sapiens doublesex and mab-3 related transcription factor 3 (DMRT3), MRNA [NM_021240] |
PDLIM3 | 5,02 | Homo sapiens PDZ and LIM domain 3 (PDLIM3), transcript variant 1, MRNA [NM_014476] | HOXB8 | 9,55 | Homo sapiens homeobox B8 (HOXB8), MRNA [NM_024016] |
PDLIM3 | 4,50 | Homo sapiens PDZ and LIM domain 3 (PDLIM3), transcript variant 1, MRNA [NM_014476] | HAND2 | 7,57 | Homo sapiens heart and neural crest derivatives expressed 2 (HAND2), MRNA [NM_021973] |
MYH11 | 3,89 | Homo sapiens myosin, heavy chain 11, smooth muscle (MYH11), transcript variant SM2B, MRNA [NM_001040113] | PDZRN4 | 6,77 | Homo sapiens PDZ domain containing ring finger 4 (PDZRN4), transcript variant 2, MRNA [NM_013377] |
FOXD1 | 3,66 | Homo sapiens forkhead box D1 (FOXD1), MRNA [NM_004472] | PDZRN4 | 6,02 | Homo sapiens PDZ domain containing ring finger 4 (PDZRN4), transcript variant 1, MRNA [NM_001164595] |
MKRN3 | 3,65 | Homo sapiens makorin ring finger protein 3 (MKRN3), MRNA [NM_005664] | TBX5 | 5,55 | Homo sapiens T-box 5 (TBX5), transcript variant 1, MRNA [NM_000192] |
PRG4 | 3,63 | Homo sapiens proteoglycan 4 (PRG4), transcript variant A, MRNA [NM_005807] | PCDH7 | 3,92 | Homo sapiens protocadherin 7 (PCDH7), transcript variant a, MRNA [NM_002589] |
HOXA11 | 3,62 | Homo sapiens homeobox A11 (HOXA11), MRNA [NM_005523] | ALX1 | 3,77 | Homo sapiens ALX homeobox 1 (ALX1), MRNA [NM_006982] |
MYH11 | 3,62 | Homo sapiens myosin, heavy chain 11, smooth muscle (MYH11), transcript variant SM1B, MRNA [NM_001040114] | PCLO | 3,64 | Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 1, MRNA [NM_033026] |
HOXA13 | 3,46 | Homo sapiens homeobox A13 (HOXA13), MRNA [NM_000522] | ALDH1A1 | 3,08 | Homo sapiens aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), MRNA [NM_000689] |
PITX1 | 3,44 | Homo sapiens paired-like homeodomain 1 (PITX1), MRNA [NM_002653] | NNAT | 3,03 | Homo sapiens neuronatin (NNAT), transcript variant 1, MRNA [NM_005386] |
OLFM4 | 3,07 | Homo sapiens olfactomedin 4 (OLFM4), MRNA [NM_006418] | ALDH1A1 | 2,95 | Homo sapiens aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), MRNA [NM_000689] |
SIX2 | 2,97 | Homo sapiens SIX homeobox 2 (SIX2), MRNA [NM_016932] | FGF10 | 2,93 | Homo sapiens fibroblast growth factor 10 (FGF10), MRNA [NM_004465] |
ZNF154 | 2,91 | Homo sapiens zinc finger protein 154 (ZNF154), MRNA [NM_001085384] | UNC5C | 2,82 | Homo sapiens unc-5 homolog C (C. elegans) (UNC5C), MRNA [NM_003728] |
SHOX2 | 2,89 | Homo sapiens short stature homeobox 2 (SHOX2), transcript variant 1, MRNA [NM_003030] | CDH12 | 2,82 | Homo sapiens cadherin 12, type 2 (N-cadherin 2) (CDH12), MRNA [NM_004061] |
KRT222 | 2,79 | Homo sapiens keratin 222 (KRT222), MRNA [NM_152349] | RSPO3 | 2,70 | Homo sapiens R-spondin 3 (RSPO3), MRNA [NM_032784] |
CYP19A1 | 2,75 | Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 2, MRNA [NM_031226] | NR2F1 | 2,67 | Homo sapiens nuclear receptor subfamily 2, group F, member 1 (NR2F1), MRNA [NM_005654] |
CDHR4 | 2,73 | Homo sapiens cadherin-related family member 4 (CDHR4), MRNA [NM_001007540] | HOXA5 | 2,56 | Homo sapiens homeobox A5 (HOXA5), MRNA [NM_019102] |
ZIC4 | 2,69 | Homo sapiens Zic family member 4 (ZIC4), transcript variant 3, MRNA [NM_032153] | IRX2 | 2,52 | Homo sapiens iroquois homeobox 2 (IRX2), transcript variant 1, MRNA [NM_033267] |
TPO | 2,52 | Homo sapiens thyroid peroxidase (TPO), transcript variant 5, MRNA [NM_175722] | COL4A5 | 2,45 | Homo sapiens collagen, type IV, alpha 5 (COL4A5), transcript variant 2, MRNA [NM_033380] |
HORMAD2 | 2,50 | Homo sapiens HORMA domain containing 2 (HORMAD2), MRNA [NM_152510] | ZNF711 | 2,34 | Homo sapiens zinc finger protein 711 (ZNF711), MRNA [NM_021998] |
IGF2 | 2,44 | Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 1, MRNA [NM_000612] | C19orf71 | 2,34 | Homo sapiens chromosome 19 open reading frame 71 (C19orf71), MRNA [NM_001135580] |
TIMD4 | 2,44 | Homo sapiens T-cell immunoglobulin and mucin domain containing 4 (TIMD4), transcript variant 1, MRNA [NM_138379] | FOLH1B | 2,33 | Homo sapiens folate hydrolase 1B (FOLH1B), MRNA [NM_153696] |
MARCO | 2,36 | Homo sapiens macrophage receptor with collagenous structure (MARCO), MRNA [NM_006770] | RSPO3 | 2,29 | Homo sapiens R-spondin 3 (RSPO3), MRNA [NM_032784] |
LYVE1 | 2,23 | Homo sapiens lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), MRNA [NM_006691] | LRFN5 | 2,28 | Homo sapiens leucine rich repeat and fibronectin type III domain containing 5 (LRFN5), MRNA [NM_152447] |
GRIN2C | 2,16 | Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2C (GRIN2C), MRNA [NM_000835] | TSGA10 | 2,24 | Homo sapiens testis specific, 10 (TSGA10), transcript variant 1, MRNA [NM_025244] |
SIM1 | 2,14 | Homo sapiens single-minded homolog 1 (Drosophila) (SIM1), MRNA [NM_005068] | IRX2 | 2,22 | Homo sapiens iroquois homeobox 2 (IRX2), transcript variant 1, MRNA [NM_033267] |
NOV | 2,07 | Homo sapiens nephroblastoma overexpressed gene (NOV), MRNA [NM_002514] | FGFR2 | 2,20 | Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 2, MRNA [NM_022970] |
BMP5 | 2,07 | Homo sapiens bone morphogenetic protein 5 (BMP5), MRNA [NM_021073] | SLC14A2 | 2,17 | Homo sapiens solute carrier family 14 (urea transporter), member 2 (SLC14A2), transcript variant 1, MRNA [NM_007163] |
CCRL1 | 2,06 | Homo sapiens chemokine (C-C motif) receptor-like 1 (CCRL1), transcript variant 1, MRNA [NM_178445] | CPXM1 | 2,11 | Homo sapiens carboxypeptidase X (M14 family), member 1 (CPXM1), transcript variant 1, MRNA [NM_019609] |
MAMDC2 | 2,05 | Homo sapiens MAM domain containing 2 (MAMDC2), MRNA [NM_153267] | PITX2 | 2,10 | Homo sapiens paired-like homeodomain 2 (PITX2), transcript variant 2, MRNA [NM_153426] |
ULK4 | 2,03 | Homo sapiens unc-51-like kinase 4 (C. elegans) (ULK4), MRNA [NM_017886] | HOXA3 | 2,10 | Homo sapiens homeobox A3 (HOXA3), transcript variant 2, MRNA [NM_153631] |
CSRNP3 | 2,03 | Homo sapiens cysteine-serine-rich nuclear protein 3 (CSRNP3), transcript variant 1, MRNA [NM_001172173] | PCLO | 2,07 | Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 2, MRNA [NM_014510] |
FNDC1 | 2,01 | Homo sapiens fibronectin type III domain containing 1 (FNDC1), MRNA [NM_032532] | TSGA10 | 2,07 | Homo sapiens testis specific, 10 (TSGA10), transcript variant 1, MRNA [NM_025244] |
TIMD4 | 1,94 | Homo sapiens T-cell immunoglobulin and mucin domain containing 4 (TIMD4), transcript variant 1, MRNA [NM_138379] | ARRDC5 | 2,07 | Homo sapiens arrestin domain containing 5 (ARRDC5), MRNA [NM_001080523] |
PCK1 | 1,94 | Homo sapiens phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1), MRNA [NM_002591] | TNFRSF13C | 2,06 | Homo sapiens tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C), MRNA [NM_052945] |
ODF3L1 | 1,93 | Homo sapiens outer dense fiber of sperm tails 3-like 1 (ODF3L1), MRNA [NM_175881] | WDR66 | 2,03 | Homo sapiens WD repeat domain 66 (WDR66), transcript variant 1, MRNA [NM_144668] |
KIR2DS4 | 1,93 | Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 (KIR2DS4), MRNA [NM_012314] | HOXB7 | 1,96 | Homo sapiens homeobox B7 (HOXB7), MRNA [NM_004502] |
BATF3 | 1,91 | Homo sapiens basic leucine zipper transcription factor, ATF-like 3 (BATF3), MRNA [NM_018664] | FOXP2 | 1,93 | Homo sapiens forkhead box P2 (FOXP2), transcript variant 4, MRNA [NM_148900] |
HOXC10 | 1,88 | Homo sapiens homeobox C10 (HOXC10), MRNA [NM_017409] | SLC14A2 | 1,86 | Homo sapiens solute carrier family 14 (urea transporter), member 2 (SLC14A2), transcript variant 1, MRNA [NM_007163] |
CAB39L | 1,87 | Homo sapiens calcium binding protein 39-like (CAB39L), transcript variant 1, MRNA [NM_030925] | KCND3 | 1,83 | Homo sapiens potassium voltage-gated channel, Shal-related subfamily, member 3 (KCND3), transcript variant 1, MRNA [NM_004980] |
RYR3 | 1,86 | Homo sapiens ryanodine receptor 3 (RYR3), transcript variant 1, MRNA [NM_001036] | IRX1 | 1,72 | Homo sapiens iroquois homeobox 1 (IRX1), MRNA [NM_024337] |
GRID1 | 1,85 | Homo sapiens glutamate receptor, ionotropic, delta 1 (GRID1), MRNA [NM_017551] | SKAP2 | 1,71 | Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), MRNA [NM_003930] |
SERPINE2 | 1,84 | Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2), transcript variant 1, MRNA [NM_006216] | ADRB1 | 1,7 | Homo sapiens adrenergic, beta-1-, receptor (ADRB1), MRNA [NM_000684] |
EFHD1 | 1,83 | Homo sapiens EF-hand domain family, member D1 (EFHD1), transcript variant 1, MRNA [NM_025202] | CXCL14 | 1,70 | Homo sapiens chemokine (C-X-C motif) ligand 14 (CXCL14), MRNA [NM_004887] |
TPPP | 1,82 | Homo sapiens tubulin polymerization promoting protein (TPPP), MRNA [NM_007030] | VEGFC | 1,59 | Homo sapiens vascular endothelial growth factor C (VEGFC), MRNA [NM_005429] |
CACNA1H | 1,79 | Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit (CACNA1H), transcript variant 1, MRNA [NM_021098] | PCDH9 | 1,54 | Homo sapiens protocadherin 9 (PCDH9), transcript variant 1, MRNA [NM_203487] |
SRPX2 | 1,79 | Homo sapiens sushi-repeat containing protein, X-linked 2 (SRPX2), MRNA [NM_014467] | SLC5A3 | 1,53 | Homo sapiens solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 (SLC5A3), MRNA [NM_006933] |
TBX15 | 1,78 | Homo sapiens T-box 15 (TBX15), MRNA [NM_152380] | HOOK2 | 1,52 | Homo sapiens hook homolog 2 (Drosophila) (HOOK2), transcript variant 1, MRNA [NM_013312] |
ZNF461 | 1,78 | Homo sapiens zinc finger protein 461 (ZNF461), MRNA [NM_153257] | Â | Â | Â |
EFHD1 | 1,78 | Homo sapiens EF-hand domain family, member D1 (EFHD1), transcript variant 1, MRNA [NM_025202] | Â | Â | Â |
COL14A1 | 1,77 | Homo sapiens collagen, type XIV, alpha 1 (COL14A1), MRNA [NM_021110] | Â | Â | Â |
SLC16A4 | 1,77 | Homo sapiens solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (SLC16A4), transcript variant 1, MRNA [NM_004696] | Â | Â | Â |
KCNE4 | 1,76 | Homo sapiens potassium voltage-gated channel, Isk-related family, member 4 (KCNE4), MRNA [NM_080671] | Â | Â | Â |
TCTEX1D4 | 1,75 | Homo sapiens Tctex1 domain containing 4 (TCTEX1D4), MRNA [NM_001013632] | Â | Â | Â |
ITIH1 | 1,75 | Homo sapiens inter-alpha-trypsin inhibitor heavy chain 1 (ITIH1), transcript variant 1, MRNA [NM_002215] | Â | Â | Â |
CLEC3B | 1,73 | Homo sapiens C-type lectin domain family 3, member B (CLEC3B), MRNA [NM_003278] | Â | Â | Â |
TNNT3 | 1,72 | Homo sapiens troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 3, MRNA [NM_001042780] | Â | Â | Â |
CRIP1 | 1,72 | Homo sapiens cysteine-rich protein 1 (intestinal) (CRIP1), MRNA [NM_001311] | Â | Â | Â |
P2RY6 | 1,72 | Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), transcript variant 2, MRNA [NM_176798] | Â | Â | Â |
ATP1B2 | 1,71 | Homo sapiens ATPase, Na+/K+ transporting, beta 2 polypeptide (ATP1B2), MRNA [NM_001678] | Â | Â | Â |
TNNT3 | 1,7 | Homo sapiens troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 1, MRNA [NM_006757] | Â | Â | Â |
TAGLN | 1,69 | Homo sapiens transgelin (TAGLN), transcript variant 1, MRNA [NM_001001522] | Â | Â | Â |
TBC1D1 | 1,68 | Homo sapiens TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (TBC1D1), MRNA [NM_015173] | Â | Â | Â |
BDKRB2 | 1,68 | Homo sapiens bradykinin receptor B2 (BDKRB2), MRNA [NM_000623] | Â | Â | Â |
LHX6 | 1,65 | Homo sapiens LIM homeobox 6 (LHX6), transcript variant 1, MRNA [NM_014368] | Â | Â | Â |
NR4A3 | 1,64 | Homo sapiens nuclear receptor subfamily 4, group A, member 3 (NR4A3), transcript variant 3, MRNA [NM_173200] | Â | Â | Â |
CRIP1 | 1,64 | Homo sapiens cysteine-rich protein 1 (intestinal) (CRIP1), MRNA [NM_001311] | Â | Â | Â |
TAGLN | 1,64 | Homo sapiens transgelin (TAGLN), transcript variant 1, MRNA [NM_001001522] | Â | Â | Â |
SYT15 | 1,64 | Homo sapiens synaptotagmin XV (SYT15), transcript variant b, MRNA [NM_181519] | Â | Â | Â |
SAMHD1 | 1,63 | Homo sapiens SAM domain and HD domain 1 (SAMHD1), MRNA [NM_015474] | Â | Â | Â |
FAM181B | 1,62 | Homo sapiens family with sequence similarity 181, member B (FAM181B), MRNA [NM_175885] | Â | Â | Â |
SGMS2 | 1,6 | Homo sapiens sphingomyelin synthase 2 (SGMS2), transcript variant 1, MRNA [NM_152621] | Â | Â | Â |
RIMBP3 | 1,6 | Homo sapiens RIMS binding protein 3 (RIMBP3), MRNA [NM_015672] | Â | Â | Â |
DES | 1,57 | Homo sapiens desmin (DES), MRNA [NM_001927] | Â | Â | Â |
TGFBI | 1,55 | Homo sapiens transforming growth factor, beta-induced, 68Â kDa (TGFBI), MRNA [NM_000358] | Â | Â | Â |
SCCPDH | 1,54 | Homo sapiens saccharopine dehydrogenase (putative) (SCCPDH), MRNA [NM_016002] | Â | Â | Â |
NMT2 | 1,54 | Homo sapiens N-myristoyltransferase 2 (NMT2), MRNA [NM_004808] | Â | Â | Â |
ITGA10 | 1,54 | Homo sapiens integrin, alpha 10 (ITGA10), MRNA [NM_003637] | Â | Â | Â |
PDIA5 | 1,54 | Homo sapiens protein disulfide isomerase family A, member 5 (PDIA5), transcript variant 1, MRNA [NM_006810] | Â | Â | Â |
CALML4 | 1,53 | Homo sapiens calmodulin-like 4 (CALML4), transcript variant 1, MRNA [NM_033429] | Â | Â | Â |
ENDOG | 1,52 | Homo sapiens endonuclease G (ENDOG), nuclear gene encoding mitochondrial protein, MRNA [NM_004435] | Â | Â | Â |