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Table 2 Top pathway maps, process networks and diseases for DEGs in SMK-NTC

From: Gene expression profiles associated with cigarette smoking and moist snuff consumption

Top scoring key ontology terms

p-value

Key Pathway Maps

 Role of CD8+ Tc1 cells in COPD

6.56E-04

 Development_GDNF signaling

3.91E-03

 Generation of cytotoxic CD8+ T cells in COPD

4.24E-03

 Development_Role of CDK5 in neuronal development

7.75E-03

 Immune resonse_HMGB1/TLR signaling pathway

8.67E-03

Key Process Networks

 Inflammation_NK cell cytotoxicity

1.53E-05

 Chemotaxis

3.53E-04

 Development_Blood vessel morphogenesis

4.85E-03

 Inflammation_Protein C signaling

6.66E-03

 Reproduction_Feeding and Neurohormone signaling

1.54E-02

Key Disease

 Lung diseases, Obstructive

2.10E-09

 Hypersensitivity

6.14E-09

 Skin Disease, Vascular

1.13E-08

 Pulmonary Diseases, Chronic Obstructive

3.68E-08

 Asthma, Asprin-Inudced

3.70E-08

  1. P-values (unadjusted) were calculated using the hypergeometric test. Only the top five categories are reported for each map