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Fig. 6 | BMC Genomics

Fig. 6

From: Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity

Fig. 6

Gro target genes form a highly-interconnected network with multiple hubs. Genes that are differentially significantly down-regulated upon Gro overexpression and that exceed the ChIP-seq score cutoffs indicated by the circles in Fig. 5 define a set of 187 high-confidence targets (the full list is provided in Additional file 6: Table S3A). a The most significantly enriched (FDR < 0.01) gene ontology groups of high-confidence Gro target genes are uniformly related to transcriptional (red bars) and developmental (black bars) regulation, confirming the role of Gro as a high-level regulatory node in the establishment of tissue fate during development. The plot indicates fold-enrichment of the indicated groups relative to random. The numbers next to the bars indicate the numbers of genes that fall into the indicated groups, and the bars are ordered according to this number with the group containing the most genes at the top. b Potential Groucho-target genes were integrated into a network analysis to visualize genetic and physical interactions of these target genes. Genetic (blue edges) and physical (orange edges) interactions were obtained from a curated set maintained by FlyMine [72]. The target gene set results in highly-connected networks with multiple hubs (8 or more edges, yellow nodes) interconnected by multiple genetic interactions

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