Fig. 2

Pathways and functional networks affected by nicotine in Thy1-neurons. a Up- and down-regulated pathways affected by nicotine. b Network of genes involved in cytokine-cytokine receptor interaction and calcium signaling pathway. c Network of genes involved in the metabolism of purine and pyrimidine. Red and green circles represent significantly up- and down- regulated genes by nicotine (P < 0.05), respectively. Csf1r and Flt1 (a), and Nme4 and Nt5e (b) are highly-connected genes with a central role in the network. c, compound; b, binding/association; inh, inhibition; ubi, ubiquitination