Fig. 2

Evolutionary emergence of the human SPATA31 gene promoter structures. Phylogenetic reconstruction of full length SPATA31 proteins (exon4 - longest coding exon) in different primates, cat, dog, rat and mouse species using the NJ method [43] with bootstrap values (500 replicates) indicated at the branches [44]. Species names are: rat (R. norvegicus), mouse (Mus musculus domesticus), cat (F. catus), dog (C. familiaris), tarsius (T. syrichta), marmoset (C. jacchus), saimiri (S. boliviensis), baboon (P. hamadryas), rhesus macaque (M. mulatta), gibbon (N. leucogenys), orangutan (P. pygmaeus), gorilla (G. gorilla), chimpanzee (P. troglodytes) and human (H. sapiens). Repetitive elements LINE/L1-PA10 (pink), LINE/L1-P3 (red) and (CCCCCT)n (blue) that were found within the SPATA31A promoter region are indicated with an arrow to show approximate integration time