Fig. 4
From: Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens
Diagram of the canonical innate immune response of the honey bee. Gene names in colour-filled boxes show evidence of significant regulation after infection by Nosema (yellow), or infection by RNA viruses and/or infestation by Varroa mites (light blue) or all pathogens (grey). Orange lines surrounding a box show increased expression and blue surrounding lines indicate decreased expression after pathogen infection –mixed orange and blue lines show genes found differentially-regulated, either up- or down-regulated across the datasets. Notably, the AMP defensin-1 exhibited increased expression in most of the datasets, but a decreased expression in the abdominal tissues of honey bees infected by Nosema. Therefore, a mixed background and outline colour are displayed. Green surrounding lines show genes found non-significantly regulated in this analysis. Solid lines with arrows show gene interactions reported in the literature, and dotted arrows indicates new potential interactions inferred from our gene co-expression network analysis