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Fig. 2 | BMC Genomics

Fig. 2

From: Sex differences in the molecular signature of the developing mouse hippocampus

Fig. 2

Changes in transcript expression through postnatal development. a: Heat-map of top 50 DE transcripts through development as ranked by p-value. Samples are organized into columns by age group, and transcripts are self-organized into rows by hierarchical clustering. Shading of boxes indicates relative levels of transcript expression within rows in terms of log2 fold change. Tan and yellow boxes indicate relatively high expression, and blue represents low expression. The majority of these transcripts [49] are down-regulated through the ages investigated, with only a single gene, Il33 (top row), increasing in expression through postnatal development. b: GO enrichment treemap for transcripts that are down-regulated through development. Boxes represent biological processes disproportionately associated (enriched) with DE genes, with the area of boxes representing degree of enrichment for each term (as determined by FDR-adjusted p-value). Boxes of the same color represent similar gene ontology terms, grouped under a global GO term in bold. c: GO enrichment treemap for transcripts that are up-regulated through development. d - g: Example transcripts for each of the 4 patterns of temporal regulation observed. Normalized read counts are plotted on the y axis, and samples of different ages are plotted along the x axis. Lines are drawn through the mean count level at each age point

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