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Fig. 8 | BMC Genomics

Fig. 8

From: Sex differences in the molecular signature of the developing mouse hippocampus

Fig. 8

Comparisons of mRNA and protein abundances. a: Linear regression analysis for mean mRNA abundance (FPKM) and protein abudance (NSAF) across all samples reveals a stasticially significant (cor.test in R, p < 0.05) though modest correlation between mRNA and protein as measured by Spearman rank correlation coefficient (Rho). Log2 transformed RNA abundance values (FPKM) are plotted along the x axis, and log2 transformed protein abundance values are plotted along the y axis. b: Linear regression analyis for mRNA and protein fold changes for comparison of 1 and 2 month old animals. Only genes with changed mRNA (q-value < 0.05) and protein (p value <0.05) are shown. The majority of these genes (16 of 22) have mRNA and proteins that change in the same direction from 1 to 2 months of age (green points). Six of the 22 genes have a protein log2 fold change that has a different sign than the RNA log2 fold change (red points)

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