Fig. 1
From: Bicodon bias can determine the role of synonymous SNPs in human diseases
Ribosome-mediated translational attenuation program and bicodons. a Graphical representation of how a sSNP can alter the ribosome-mediated translational attenuation program and, ultimately, final protein conformation. Consequently, this can affect protein function leading to pathological phenotypes. b Simplified graph showing codons (green boxes) and bicodons (red ellipses) within an mRNA sequence. Owing to the superposition of bicodons, each codon is part of two different bicodons in a given open reading frame. Alterations of the ribosome-mediated translational attenuation program, with the resulting alternative protein conformations and functions, could be encoded by bicodons, rather than by codons