Fig. 4
From: Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence
Analysis of gene expression data based on a metabolic model for strain MC58. a Comparison of elementary mode activities in MC58 and α522. The histogram depicts differences in the elementary mode activities (ordinate) for each of the elementary metabolic modes (abscissa) as defined in the Additional file 3: S2 for strain MC58 (red) and α522 (blue) based on gene expression data in human blood. b Inferred differences in metabolic fluxes between strain MC58 and strain α522 in blood based on a metabolic model for strain MC58. Internal metabolites which are considered to have balanced concentrations are given by dark green spheres, external metabolites which are allowed to accumulate or to be consumed by green cones, and reactions together with their corresponding numbers as light green boxes. The reactions for all reaction numbers are given in the Additional file 3: S2. Arrows connect reaction with metabolites. Red coloring indicates higher fluxes in MC58 compared to strain α522, whereas blue colouring indicates that the flux is slightly enhanced in α522. Asterisks along with pink colouring indicate that the reaction has an opposite direction in both strains