Fig. 1

Methylation of CpG sites in CLL and control samples. a The pie chart shows the genomic distribution of CpG sites assayed in RRBS-seq. b Fractions of the CpG sites de-methylated in CLL along different genomic regions are compared. To control the noise introduced during data preparation and process, only the CpGs having a considerable methylation change, i.e., the methylation difference between CLL and control is greater than 0.3, were considered here. c The results of a classic hierarchical algorithm show that methylation of the CpGs located in gene regulatory loci can distinguish CLL (in red color) from control (black)