Fig. 3

Functional analysis of dREs. Enrichments of the dREs are plotted for the genes (a) up-regulated in CLL and (b) down-regulated in CLL. The * indicates that binomial test p < 0.001. c Biological process association is compared across different gene groups. Human genes are categorized in light of the distribution of dREs and sREs. GS is a set of the genes harboring the gained dREs and sREs in their neighborhood. Similarly, GL represents the genes connected with both the gained and lost dREs, while LS is the genes linked to the lost dREs and sREs. eG represents the genes associated exclusively with the gained dREs, while eS and eL are the genes having only the shared dRE(s) and the lost dRE(s), respectively, in their neighborhood. The values presented in this heatmap are the enrichment fold with respect to all human genes. Zeros indicate insignificant enrichment (i.e, p > 0.001) in the corresponding cases