Fig. 4

Transcriptional activity of S. mutans alone and in co-culture with A. act.. Heatmaps show relative gene expression of S. mutans after 8 and 24 h of biofilm growth in dual species biofilms with A. act. compared with the expression in single-species biofilms (left two columns) or after 6, 8, 10, 12 and 24 h of biofilm growth in dual species biofilms compared with gene expression at 4 h (right five columns). Selected genes were significantly differentially expressed in at least one condition (FDR ≤ 0.05) and are grouped according to function in panel a-k andordered based on their position in the S. mutans chromosome