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Fig. 2 | BMC Genomics

Fig. 2

From: Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Fig. 2

Enrichment of SNPs lying within enhancers. Q-Q plots visualizing the p-value enrichment of sets of SNPs mapping within genomic intervals identified as regions of putative enhancers or key transcription factor binding sites. The p-values describe the association of a specific SNP with prostate (iCOGs in panel a & b; PRACTICAL in panel c) and breast cancer (BCAC in panel d & e). The genomic intervals represent regions bound by MED12, BRD4 with a H3K27Ac modification in prostate cancer cell lines (LNCaP and VCaP), or in overlapping regions profiled for a combination of the features in the prostate cancer (PC) cell-lines as indicated (a, c, d), intersected with AR binding sites (b), or regions found in MCF7 (e), as indicated in the legends. (f) Q-Q plots visualizing the p-value enrichment of schizophrenia associated SNPs (PGC) lying within enhancers identified in Schwann cells

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BMC Genomics

ISSN: 1471-2164

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