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Fig. 3 | BMC Genomics

Fig. 3

From: Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Fig. 3

Circular plots of GWAS significant SNPs overlapping with putative super-enhancers. The outmost circles depict chromosome-wise histograms showing p-values of SNP loci (LD r^2 < 0.2 within 1Mbase) representatives for SNPs in iCOGS (a), for SNPs in BCAC (b), and for SNPs associated with schizophrenia according to PGC (c). GWAS-significant SNPs are labeled and the nearby genes are also indicated. The inmost circle represents super-enhancers regions identified in prostate cancer cells (SE_PC_BRD4_MED12_H3K27Ac) (a), breast cancer cells (SE_MCF7_BRD4) (b), and in Schwann cells (SE_Schwann_BRD4) (c) that were most enriched of low p-value SNPs

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BMC Genomics

ISSN: 1471-2164

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