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Table 1 INTS12 cis-eQTLs at 4q24 locus

From: Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways

SNP Position FEV1 P-value INTS12 eQTL FDR INTS12 effect size GSTCD eQTL FDR GSTCD effect size
rs11732650 106973680 6.83E-09 0.000397993 −0.53 1 0
rs11722225 106985879 7.08E-09 0.000397993 −0.53 1 0
rs11726124 106985945 6.63E-09 0.000397993 −0.53 1 0
rs11728716 106975445 8.44E-09 0.000397993 −0.53 1 0
rs17036090 106813023 3.84E-08 0.000397993 −0.51 1 0.01
rs11735851 106916703 1.90E-09 0.000397993 −0.51 1 0.02
rs17036225 106929541 3.33E-09 0.000397993 −0.51 1 0.02
rs11736859 106928234 2.86E-09 0.000397993 −0.51 1 0.02
rs11727745 106935976 5.47E-09 0.000397993 −0.51 1 0.02
rs10516528 106959042 6.27E-09 0.000397993 −0.51 1 0.02
rs17036139 106852106 1.25E-09 0.000397993 −0.51 1 0.02
rs11727189 106838589 3.38E-09 0.000397993 −0.51 1 0.02
rs11731417 106965461 5.96E-09 0.000397993 −0.53 1 0
rs11733287 106924788 2.32E-09 0.000397993 −0.53 1 0
rs11728044 106824235 1.95E-09 0.000397993 −0.51 1 0.02
rs11733225 106924812 2.34E-09 0.000397993 −0.51 1 0.02
rs10516525 106887474 1.44E-09 0.000397993 −0.51 1 0.02
rs11724839 106857705 1.79E-09 0.000397993 −0.51 1 0.02
rs10516526 106908353 6.67E-10 0.000397993 −0.51 1 0.02
rs17036142 106854185 1.11E-09 0.000397993 −0.51 1 0.02
rs12374256 106836810 1.88E-09 0.000658031 −0.52 1 0.03
rs11097901 106949382 6.32E-09 0.000953622 −0.47 1 0.02
  1. Genome-wide significant SNPs for lung function parameter forced expiratory volume in the first second (FEV1) also correlate with INTS12 expression in the human lung (FDR < 0.001). This observation is not true for the expression of neighbouring GSTCD, supporting the hypothesis that altered expression of INTS12 is driving the association signal for lung function. Effect size is defined as the slope of linear regression line relative to reference allele normalized as an expression of 1. The eQTL data was obtained from Genotype-Tissue Expression project, while per SNPs lung function significance values in linkage disequilibrium with INTS12 (r2 > 0.8) are from Repapi et al. study (Repapi et al. 2010)[3]