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Table 2 Deregulation of a core regulome genes due to INTS12 knockdown

From: Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways

48 h and 120 h consensus genes

FOLD CHANGES

48 h

120 h

Scrambled vs D-siRNA A

Scrambled vs D-siRNA C

Scrambled vs D-siRNA A

Scrambled vs D-siRNA C

LEP

4.51

16.62

29.16

23.41

AC005863.1

3.35

3.90

9.60

5.55

OLFML2A

1.71

2.55

8.02

2.71

SESN3

2.98

2.01

6.80

2.53

TNS1

2.66

4.73

6.43

6.12

NEK7

2.42

2.30

5.67

3.95

MAN1A1

1.82

2.03

5.26

2.67

MAF

2.81

4.89

4.56

5.47

BMF

3.81

3.48

4.49

4.49

SCPEP1

1.53

1.56

3.76

1.26

PBXIP1

1.88

2.14

3.49

2.32

CBX1

2.04

2.28

3.01

3.39

ENDOD1

1.80

1.82

2.99

3.04

SGK1

1.63

1.54

2.89

1.93

HSPB1

1.65

1.47

2.75

1.48

RNF152

1.55

1.84

2.55

1.97

SERPINA1

2.85

2.71

2.48

2.79

PGAM1

1.64

1.70

2.47

2.02

ASPH

1.59

1.66

2.44

2.37

MAMDC2

2.56

3.17

2.43

7.40

SHROOM2

1.66

1.95

2.42

1.80

EPHB2

1.55

2.12

2.20

2.63

ITGB6

1.84

2.47

2.19

4.01

IL1R1

2.16

2.02

2.16

1.66

TGFBI

1.99

2.75

2.00

5.83

SLITRK6

1.80

2.11

1.86

2.62

PNRC2

1.63

1.56

1.31

1.36

PHACTR3

0.43

0.53

0.43

0.52

IL8

0.45

0.49

0.42

0.18

CRCT1

0.34

0.54

0.39

0.58

CNOT6

0.59

0.64

0.39

0.56

LIF

0.43

0.41

0.38

0.35

KRT80

0.58

0.38

0.32

0.33

CXCL3

0.43

0.35

0.28

0.20

IL1B

0.52

0.38

0.17

0.33

CXCL5

0.54

0.47

0.17

0.34

IL1A

0.55

0.65

0.09

0.49

IL6

0.33

0.48

0.03

0.20

  1. The table is showing the fold changes of consensus differentially expressed genes after 48 h and 120 h since the D-siRNA A and C transfections