Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract

Table 1 The 20 most strongly up-regulated mRNAs in the liver of cows fed grape seed and grape marc meal extract (GSGME) versus control cows at 1 week postpartum

Gene symbol	mRNA description	FC^a	P-value
TOP2A	topoisomerase (DNA) II alpha 170 kDa	2.91	0.013
CDKN3	cyclin-dependent kinase inhibitor 3	2.64	0.010
ARHGAP11A	Rho GTPase activating protein 11A	2.61	0.029
STMN1	stathmin 1	2.57	0.015
ECT2	epithelial cell transforming sequence 2 oncogene	2.53	0.023
DEPDC1	DEP domain containing 1	2.51	0.015
CENPA	centromere protein A	2.49	0.006
CENPF	centromere protein F, 350/400 kDa (mitosin)	2.45	0.017
CKAP2	cytoskeleton associated protein 2	2.39	0.024
PRR11	proline rich 11	2.32	0.036
KIF11	kinesin family member 11	2.25	0.007
KIF20A	kinesin family member 20A	2.21	0.017
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta	2.20	0.004
LOC618147	histone cluster 1, H2ai-like	2.17	0.002
KIF4A	kinesin family member 4A	2.13	0.018
LOC787465	histone H2B type 1-like	2.10	0.006
GAS2L3	growth arrest-specific 2 like 3	1.99	0.018
SMC4	structural maintenance of chromosomes 4	1.98	0.011
SMC2	structural maintenance of chromosomes 2	1.96	0.011
RRM2	ribonucleotide reductase M2	1.95	0.046
CASC5	cancer susceptibility candidate 5	1.93	0.029
ESCO2	establishment of cohesion 1 homolog 2	1.93	0.032
HIST2H2BF	histone cluster 2, H2bf	1.91	0.039
HELLS	helicase, lymphoid-specific	1.90	0.013

^aThe FC was calculated from the signal log ratios as follows: 2^{Signal log ratio} if signal log ratio ≥ 0 and (−1) × 2^{–(Signal log ratio)} if signal log ratio < 0. Signal log ratios were calculated from n = 6 microarrays per group

ISSN: 1471-2164