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Table 1 The 20 most strongly up-regulated mRNAs in the liver of cows fed grape seed and grape marc meal extract (GSGME) versus control cows at 1 week postpartum

From: Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract

Gene symbol mRNA description FCa P-value
TOP2A topoisomerase (DNA) II alpha 170 kDa 2.91 0.013
CDKN3 cyclin-dependent kinase inhibitor 3 2.64 0.010
ARHGAP11A Rho GTPase activating protein 11A 2.61 0.029
STMN1 stathmin 1 2.57 0.015
ECT2 epithelial cell transforming sequence 2 oncogene 2.53 0.023
DEPDC1 DEP domain containing 1 2.51 0.015
CENPA centromere protein A 2.49 0.006
CENPF centromere protein F, 350/400 kDa (mitosin) 2.45 0.017
CKAP2 cytoskeleton associated protein 2 2.39 0.024
PRR11 proline rich 11 2.32 0.036
KIF11 kinesin family member 11 2.25 0.007
KIF20A kinesin family member 20A 2.21 0.017
BUB1B budding uninhibited by benzimidazoles 1 homolog beta 2.20 0.004
LOC618147 histone cluster 1, H2ai-like 2.17 0.002
KIF4A kinesin family member 4A 2.13 0.018
LOC787465 histone H2B type 1-like 2.10 0.006
GAS2L3 growth arrest-specific 2 like 3 1.99 0.018
SMC4 structural maintenance of chromosomes 4 1.98 0.011
SMC2 structural maintenance of chromosomes 2 1.96 0.011
RRM2 ribonucleotide reductase M2 1.95 0.046
CASC5 cancer susceptibility candidate 5 1.93 0.029
ESCO2 establishment of cohesion 1 homolog 2 1.93 0.032
HIST2H2BF histone cluster 2, H2bf 1.91 0.039
HELLS helicase, lymphoid-specific 1.90 0.013
  1. aThe FC was calculated from the signal log ratios as follows: 2Signal log ratio if signal log ratio ≥ 0 and (−1) × 2–(Signal log ratio) if signal log ratio < 0. Signal log ratios were calculated from n = 6 microarrays per group