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Table 3 Top-ranked genes contributing to the first dimension of MFA analysis

From: A transcriptome multi-tissue analysis identifies biological pathways and genes associated with variations in feed efficiency of growing pigs

Genea

Full name (Associated biological process)

r

PSEN1

Presenilin 1 (T cell receptor signaling pathway; regulation of MAP kinase activity)

0.84

PCIF1

PDX1 C-terminal inhibiting factor 1 (Negative regulation of phosphatase activity)

0.77

RPL6

Ribosomal protein L6 (Translation)

0.77

IPP

Intracisternal A particle-promoted polypeptide (Ubiquitination)

0.77

RPL14

Ribosomal protein L14 (Translation)

0.76

PHYH

Phytanoyl-CoA 2-hydroxylase (Fatty acid oxidation)

0.76

PLA2G12A

Phospholipase A2 group XIIA (Lipid catabolic process)

0.75

HEATR4

HEAT repeat containing 4

0.75

ZNF174

Zinc finger protein 174 (Transcription)

0.74

USP33

Ubiquitin specific peptidase 33 (Ubiquitin-dependent protein process)

0.74

CD40

CD40 molecule (Immune response)

−0.79

NTN1

Netrin 1 (Apoptotic process)

−0.78

POLR3H

Polymerase (RNA) III subunit H (Immune response)

−0.77

LZTFL1

Leucine zipper transcription factor like 1 (Protein localization)

−0.76

CYB561A3

Cytochrome b561 family member A3 (Oxido-reduction)

−0.75

H2-Q4

Histocompatibility 2, Q region locus 4 (Antigen processing)

−0.75

CTSC

Cathepsin C (Immune response)

−0.74

UQCRB

Ubiquinol-cytochrome c reductase binding protein (Oxido-reduction)

−0.74

PIKFYVE

Phosphoinositide kinase, FYVE-type zinc finger containing (Signal transduction)

−0.74

DST

Dystonin (Cytoskeleton organization)

−0.74

PHYH

Phytanoyl-CoA 2-hydroxylase (Fatty acid oxidation)

−0.72

  1. aTop-ranked contributors in transcriptomics variability were identified by a multiple factor analysis (MFA). Unique genes were ranked according to the correlation coefficient (r) calculated between their corresponding molecular probe(s) and the first dimension of the MFA that opposed pigs from the low RFI line to pigs from the high RFI line. When different probes corresponded to the same unique gene, only the highest r value for positive correlation or the lowest r value for negative correlation, respectively, is indicated. The main biological process associated to each gene in Entrez database was also indicated. RFI Residual feed intake