A transcriptome multi-tissue analysis identifies biological pathways and genes associated with variations in feed efficiency of growing pigs

Table 5 Summary of the main liver-specific biological processes

GO terms^a	Nb DEG	E score	P-value
Over-expressed in pigs from the low RFI line
GO:0009100 ~ glycoprotein metabolic process	9	1.4	0.012
GO:0043691 ~ reverse cholesterol transport	3	1.0	0.024
GO:0007242 ~ intracellular signaling cascade	28	1.0	0.042
Under-expressed in pigs from the low RFI line
GO:0006952 ~ defense response	17	1.9	0.013
hsa00591:Linoleic acid metabolism	5	1.4	0.001
GO:0042981 ~ regulation of apoptosis	19	1.4	0.034
GO:0033559 ~ unsaturated fatty acid metabolic process	4	1.3	0.035
GO:0006468 ~ protein amino acid phosphorylation	16	1.3	0.049
GO:0050778 ~ positive regulation of immune response	7	1.1	0.016
GO:0006959 ~ humoral immune response	6	1.0	0.005

^aGenes that were differentially expressed between pigs from the low or high RFI lines in liver only were clustered according to considered to gene ontology (GO) terms for biological processes and Genomes biological pathways (hsa). Significantly-enriched clusters (E ≥ 1; P < 0.05) were listed with the enrichment (E) score, the number (Nb) of differentially expressed genes (DEG) in each cluster and P-value

ISSN: 1471-2164