From: Tissue and time specific expression pattern of interferon regulated genes in the chicken
Spleen | Lung | |||||||
---|---|---|---|---|---|---|---|---|
Pathway name | Rank | Impact factor | input genes/genes in pathway | corrected gamma p-value | Rank | Impact factor | input genes/genes in pathway | corrected gamma p-value |
Leukocyte transendothelial migration | 1 | 138.9 | 16/119 | 6.56E-59 | 52 | 3.1 | 7/119 | 0.190507 |
Cell adhesion molecules (CAMs) | 2 | 123.4 | 15/134 | 3.30E-52 | 54 | 2.9 | 7/134 | 0.209069 |
Phosphatidylinositol signaling system | 21 | 5.7 | 6/76 | 0.02196 | 1 | 27.5 | 7/76 | 3.22E-11 |
Jak-STAT signaling pathway | 3 | 16.0 | 32/155 | 2.00E-06 | 2 | 18.7 | 24/155 | 1.55E-07 |
Toll-like receptor signaling pathway | 4 | 14.9 | 24/102 | 5.22E-06 | 3 | 17.2 | 19/102 | 6.12E-07 |
Circadian rhythm | 11 | 8.5 | 3/13 | 0.00192 | 4 | 17.1 | 1/13 | 7.32E-07 |
Graft-versus-host disease | 5 | 14.4 | 6/42 | 8.59E-06 | 7 | 11.7 | 6/42 | 1.02E-04 |
Pathways in cancer | 6 | 13.6 | 63/330 | 1.89E-05 | 5 | 13.4 | 39/330 | 2.19E-05 |
Complement and coagulation cascades | 31 | 4.0 | 11/69 | 0.08904 | 6 | 12.7 | 13/69 | 4.11E-05 |
Axon guidance | 7 | 12.4 | 30/129 | 5.31E-05 | 49 | 3.2 | 9/129 | 0.174755 |
Bladder cancer | 8 | 11.7 | 14/42 | 1.05E-04 | 35 | 3.9 | 5/42 | 0.098477 |
Hematopoietic cell lineage | 9 | 11.6 | 17/87 | 1.19E-04 | 9 | 8.5 | 11/87 | 0.001957 |
MAPK signaling pathway | 10 | 10.9 | 44/272 | 2.21E-04 | 24 | 4.7 | 19/272 | 0.052229 |
TGF-beta signaling pathway | 35 | 3.8 | 13/87 | 0.10746 | 8 | 8.9 | 13/87 | 0.001400 |
ECM-receptor interaction | 12 | 7.9 | 20/84 | 0.00334 | 10 | 8.1 | 13/84 | 0.002819 |
Type II diabetes mellitus | 22 | 5.6 | 7/45 | 0.02363 | 11 | 8.0 | 7/45 | 0.003114 |
Long-term depression | 13 | 7.8 | 17/75 | 0.00361 | 44 | 3.2 | 2/75 | 0.170290 |
Calcium signaling pathway | 38 | 3.7 | 23/182 | 0.11330 | 13 | 7.6 | 17/182 | 0.004315 |
Type I diabetes mellitus | 14 | 7.5 | 8/44 | 0.00464 | 12 | 7.6 | 6/44 | 0.004176 |
Adherens junction | 15 | 7.0 | 11/78 | 0.00718 | 33 | 4.0 | 3/78 | 0.091871 |
Allograft rejection | 16 | 7.0 | 7/38 | 0.00741 | 15 | 6.7 | 5/38 | 0.009661 |
Epithelial cell signaling in Helicobacter pylori infection | 17 | 6.9 | 15/68 | 0.008295 | 16 | 6.4 | 9/68 | 0.011897 |
Apoptosis | 25 | 5.5 | 15/89 | 0.02658 | 14 | 6.8 | 11/89 | 0.008871 |
Amyotrophic lateral sclerosis (ALS) | 18 | 6.4 | 10/56 | 0.01234 | 39 | 3.6 | 5/56 | 0.123832 |
Focal adhesion | 19 | 6.2 | 35/203 | 0.01415 | 34 | 4.0 | 17/203 | 0.095007 |
Small cell lung cancer | 20 | 6.0 | 18/86 | 0.017727 | 30 | 4.1 | 9/86 | 0.083372 |
Systemic lupus erythematosus | 26 | 5.4 | 10/144 | 0.02984 | 17 | 5.7 | 7/144 | 0.021797 |
GnRH signaling pathway | 23 | 5.6 | 18/103 | 0.02426 | 32 | 4.1 | 8/103 | 0.085545 |
PPAR signaling pathway | 24 | 5.6 | 14/70 | 0.02482 | - | - | - | - |
Long-term potentiation | 41 | 3.3 | 11/73 | 0.15896 | 19 | 5.4 | 5/73 | 0.028017 |