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Table 5 KEGG Pathway Express analysis

From: Tissue and time specific expression pattern of interferon regulated genes in the chicken

 

Spleen

Lung

Pathway name

Rank

Impact factor

input genes/genes in pathway

corrected gamma p-value

Rank

Impact factor

input genes/genes in pathway

corrected gamma p-value

Leukocyte transendothelial migration

1

138.9

16/119

6.56E-59

52

3.1

7/119

0.190507

Cell adhesion molecules (CAMs)

2

123.4

15/134

3.30E-52

54

2.9

7/134

0.209069

Phosphatidylinositol signaling system

21

5.7

6/76

0.02196

1

27.5

7/76

3.22E-11

Jak-STAT signaling pathway

3

16.0

32/155

2.00E-06

2

18.7

24/155

1.55E-07

Toll-like receptor signaling pathway

4

14.9

24/102

5.22E-06

3

17.2

19/102

6.12E-07

Circadian rhythm

11

8.5

3/13

0.00192

4

17.1

1/13

7.32E-07

Graft-versus-host disease

5

14.4

6/42

8.59E-06

7

11.7

6/42

1.02E-04

Pathways in cancer

6

13.6

63/330

1.89E-05

5

13.4

39/330

2.19E-05

Complement and coagulation cascades

31

4.0

11/69

0.08904

6

12.7

13/69

4.11E-05

Axon guidance

7

12.4

30/129

5.31E-05

49

3.2

9/129

0.174755

Bladder cancer

8

11.7

14/42

1.05E-04

35

3.9

5/42

0.098477

Hematopoietic cell lineage

9

11.6

17/87

1.19E-04

9

8.5

11/87

0.001957

MAPK signaling pathway

10

10.9

44/272

2.21E-04

24

4.7

19/272

0.052229

TGF-beta signaling pathway

35

3.8

13/87

0.10746

8

8.9

13/87

0.001400

ECM-receptor interaction

12

7.9

20/84

0.00334

10

8.1

13/84

0.002819

Type II diabetes mellitus

22

5.6

7/45

0.02363

11

8.0

7/45

0.003114

Long-term depression

13

7.8

17/75

0.00361

44

3.2

2/75

0.170290

Calcium signaling pathway

38

3.7

23/182

0.11330

13

7.6

17/182

0.004315

Type I diabetes mellitus

14

7.5

8/44

0.00464

12

7.6

6/44

0.004176

Adherens junction

15

7.0

11/78

0.00718

33

4.0

3/78

0.091871

Allograft rejection

16

7.0

7/38

0.00741

15

6.7

5/38

0.009661

Epithelial cell signaling in Helicobacter pylori infection

17

6.9

15/68

0.008295

16

6.4

9/68

0.011897

Apoptosis

25

5.5

15/89

0.02658

14

6.8

11/89

0.008871

Amyotrophic lateral sclerosis (ALS)

18

6.4

10/56

0.01234

39

3.6

5/56

0.123832

Focal adhesion

19

6.2

35/203

0.01415

34

4.0

17/203

0.095007

Small cell lung cancer

20

6.0

18/86

0.017727

30

4.1

9/86

0.083372

Systemic lupus erythematosus

26

5.4

10/144

0.02984

17

5.7

7/144

0.021797

GnRH signaling pathway

23

5.6

18/103

0.02426

32

4.1

8/103

0.085545

PPAR signaling pathway

24

5.6

14/70

0.02482

-

-

-

-

Long-term potentiation

41

3.3

11/73

0.15896

19

5.4

5/73

0.028017

  1. Shown are the 30 most significantly affected pathways in spleen and lung ranked according to their corrected gamma p-value (the value which was used for the ranking is shown in bold letters); “Rank” is the rank of a pathway among all significantly affected pathways according to its impact factor; the “Impact factor” of a pathway is calculated from a probabilistic term considering the proportion of differentially regulated genes on the pathway and gene perturbation factors of all genes in the pathway [46]