Table 5 Significant functional annotations of our final set of candidate genes according to Ingenuity® Pathway Analysis (IPA®)
From: Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes
Diseases or functions annotation | p-value | Candidate genes involved |
|---|---|---|
Proliferation of nervous tissue cell lines | 2.07E-05 | AKT1,NRP1 |
Action potential of embryonic stem cell lines | 1.02E-03 | KCNH2 |
Arrest in growth of nervous tissue cell lines | 1.02E-03 | NRP1 |
Formation of cranium | 1.02E-03 | MMP2 |
Quiescence of nervous tissue cell lines | 1.02E-03 | NRP1 |
Schizophrenia | 1.55E-03 | AKT1,KCNH2,PPP3CB,SMARCA2 |
Generation of plasmacytoid dendritic cells | 4.08E-03 | AKT1 |
Induction of CD4+ T-lymphocytes | 5.10E-03 | PRKG1 |
Induction of Th17 cells | 5.10E-03 | PRKG1 |
Binding of cells | 5.40E-03 | MMP2,NPPB,NRP1 |
Permeability of blood–brain barrier | 6.11E-03 | MMP2 |
Gene silencing | 8.14E-03 | SMARCA2 |
Loss of neurons | 1.32E-02 | ATN1 |
Rasmussen’s encephalitis | 1.42E-02 | PPP3CB |
Cognition | 1.52E-02 | AKT1 |
Neuropathic pain | 2.12E-02 | KCNH2 |
Apoptosis of dendritic cells | 2.22E-02 | AKT1 |
Release of nitric oxide | 2.32E-02 | AKT1 |
Quantity of neurons | 2.42E-02 | ATN1 |
Transcription of RNA | 2.84E-02 | AKT1,ATN1,SMARCA2 |
Epilepsy | 3.13E-02 | HSPA1L,NPPB |