Fig. 1

Cumulative percentages of R² values. GO categories of biological process (green), molecular function (red) and cellular component (blue) are plotted together. The lighter green, red, and blue lines represent the results of permutation tests that produced 1000 OLS regressions from randomly sampled transcripts and proteins of equivalent categorical sizes of biological process, molecular function, and cellular component, respectively. The observed data from all three GO annotations have distributions with a positive skew, displaying how there are categories of both molecular function and cellular components that are more predictive of protein expression than randomly associated transcripts and proteins. The data is plotted with a bin width is 0.05, and the representative line is Gaussian smoothed. Duplicate categories that contain the same molecules and have the same R² value as another category are not represented