Table 3 Results of multiple regression analyses of R2 value (dependent variable) against transcription and translation rates and mRNA and protein half-lives (independent variables)
From: The predictive nature of transcript expression levels on protein expression in adult human brain
Estimate | Std. error | t-value | p | |
|---|---|---|---|---|
Biological process | ||||
Intercept | 4.23E-02 | 8.07E-02 | 0.52 | 0.60 |
Transcription rate | 1.09E-02 | 4.06E-03 | 2.69 | <0.01 |
Translation rate | 8.86E-05 | 5.11E-05 | 1.73 | 0.08 |
mRNA half-life | -4.32E-03 | 5.60E-03 | −0.77 | 0.44 |
Protein half-life | 5.61E-04 | 1.97E-04 | 2.84 | <0.01 |
R2 = 0.08, F(4, 207) = 4.315, p-value = 0.002 | ||||
Molecular function | ||||
Intercept | 3.41E-01 | 1.02E-01 | 3.35 | <0.01 |
Transcription rate | -8.63E-03 | 5.74E-03 | −1.5 | 0.14 |
Translation rate | 4.12E-05 | 2.89E-05 | 1.43 | 0.16 |
mRNA half-life | -1.38E-02 | 6.71E-03 | −2.06 | <0.05 |
Protein half-life | -2.58E-04 | 1.97E-04 | −1.31 | 0.19 |
R2 = 0.13, F(4, 87) = 3.125, p-value = 0.02 | ||||
Cellular compartment | ||||
Intercept | -1.89E-01 | 1.05E-01 | -1.80 | 0.08 |
Transcription rate | -2.99E-02 | 8.26E-03 | −3.62 | <0.01 |
Translation rate | 8.71E-05 | 6.15E-05 | 1.42 | 0.16 |
mRNA half-life | 3.63E-02 | 6.71E-03 | 5.40 | <0.01 |
Protein half-life | -8.21E-04 | 2.79E-04 | −2.94 | <0.01 |
R2 = 0.40, F(4, 63) = 10.41, p-value < 0.001 | ||||