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Table 2 Proteins differentially abundant in PK1 neuroblastoma cells knockdown for the prion protein. Four proteins showed increased levels (positive FC) and two decreased levels (negative FC) in knockdown cells. Fold change ± 2 (ANOVA p < 0.05) was used as threshold for protein identification

From: Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

Spot #

Protein [Mus musculus]

Gene

Mw(kDa)

pI

SC(%)

FC

268; 272; 276

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialc

Sdha

73.6

7.3

16

−2.1; − 2.3; − 3.0

278

Structural maintenance of chromosomes protein 2

Smc2

13.5

9.1

19

+4.4

279

T-complex protein 1 subunit theta

Cct8

60.1

5.3

31

+4.7

316

ATP synthase subunit beta, mitochondrial

Atpb

56.3

5.1

17

+6.3

522

Elongation factor Tu, mitochondrial

Tufm

49.9

7.9

14

−2.3

938

Acyl-protein thioesterase 1

Lypla1

25.0

6.2

10

+2.0

  1. SC sequence coverage, FC fold change
  2. cSDHA identified in three different spots with similar fold differences