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Fig. 3 | BMC Genomics

Fig. 3

From: MitoRS, a method for high throughput, sensitive, and accurate detection of mitochondrial DNA heteroplasmy

Fig. 3

RCA does not introduce sequencing errors. The difference in absolute frequencies between the non-amplified samples and the RCA samples was computed for each single position of the reference genome. The positions with a non-null difference are plotted as a bar. a SNV and b indels are plotted in two different graphs. The two non-concordant positions from the SNV panel resulting from unspecific RCA amplification are marked with a star (see the Additional file 2: Supporting Information). The calculation was made as the average frequency within the four sample replicates. Only passing filter variants were considered. Left panel: SNV, right panel: indels

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