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Table 4 Selected downregulated genes in the Malpighian tubules following cold acclimation whose putative function in relation to cold tolerance is discussed in the text

From: Effects of cold-acclimation on gene expression in Fall field cricket (Gryllus pennsylvanicus) ionoregulatory tissues

Function Description Fold change P-value Species
Autophagy Autophagy-Related Protein 2-Like Protein B -2.1 1.5E-7 Zn
Circadian Timeless -3.0 3.3E-13 Gb
Cytoskeleton Microtubule-Associated Proteins 1A 1B Light Chain 3C -4.9 8.5E-23 Zn
Epidermal Growth Factor Receptor Kinase Substrate 8-Like Isoform X1 -2.4 1.9E-9 Md
Gamma-Tubulin Complex Component 3 -2.0 4.7E-9 Zn
Development Juvenile Hormone-Inducible -10.6 3.8E-50 Aa
Ion transport/pH regulation Carbonic Anhydrase 9 -4.2 2.1E-33 Zn
Carbonic Anhydrase 1 -2.2 5.9E-15 Tc
V-ATPase Subunit D -2.1 1.2E-14 Lm
Phosphorylation Inositol Monophosphatase -6.9 1.1E-58 Zn
Serine Threonine-Protein Phosphatase 2B Catalytic Subunit 2-Like Isoform X2 -2.1 9.0E-14 Tc
Protein folding/chaperone Heat Shock Protein 67B2 -2.8 1.6E-16 Zn
Repair/detoxicant/antioxidant Antioxidant Enzyme -2.9 3.7E-23 Go
Cytochrome P450 -2.9 1.4E-11 Bt
Cytochrome P450 4C1 -2.7 3.2E-22 Zn
Cytochrome P450 6A14 -2.5 3.2E-13 Zn
Cytochrome P450 9E2 -2.3 1.4E-11 Zn
Cytochrome P450 (partial) -2.3 3.6E-12 Zn
Cytochrome P450 9E1 -2.2 3.3E-14 Dp
Glutathione S-Transferase -3.2 1.8E-23 Bt
Glutathione S-Transferase Theta 1 -3.1 1.9E-28 Lm
  1. For a full list of the 1009 downregulated Malpighian tubule genes, see Additional file 2: Spreadsheet S1. P-values were adjusted for false discovery rate (FDR). For each gene, the species with the highest sequence similarity via BLAST is given. Species codes: Aa (Aedes aegypti), Bt (Bemisia tabaci), Dp (Diplotera punctata), Gb (Gryllus bimaculatus), Go (Gryllotalpa orientalis), Lm (Locusta migratoria), Md (Microplitis demolitor), Tc (Tribolium castaneum), Zn (Zootermopsis nevadensis)