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Fig. 4 | BMC Genomics

Fig. 4

From: The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model

Fig. 4

Expression profile clustering and enrichment analyses. a DE genes were clustered based on their expression profiles in HD cells. The two largest clusters created by the CLICK algorithm show a gradual increase and decrease in gene expression, respectively. Expression patterns were standardized to mean zero and standard deviation one. Error bars correspond to one standard deviation. b The gene clusters were subjected to a functional enrichment analysis using the TANGO algorithm to identify overrepresented biological processes and/or molecular functions. The –log10(corrected P-values) of all functional terms found to be significant are plotted. Terms found to be overrepresented in cluster 1 are indicated in red, those found in cluster 2 are indicated in blue. When correcting for multiple testing, no overrepresented functional terms could be detected for any of the twelve other clusters. c A transcription factor binding motif enrichment analysis of the promoter regions of the clustered genes was performed using the PRIMA algorithm. The –log10(P-values) of all motifs found to be significant were plotted. Motifs found to be overrepresented in cluster 1 are indicated in red, those found in cluster 2 are indicated in blue. For each transcription factor the corresponding TransFac DB accession number is listed between parentheses on the y-axis

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