Table 2 Test for associations between the inhibitory codon pairs and various gene expression variables

ρ

P value

Permutation

P value

τ

P value

Permutation

P value

mRNA synthesis rate (Cramer 1)

−0.23

5.1E-51

1.0E-04

−0.18

9.7E-51

1.0E-04

mRNA synthesis rate (Cramer 2)

−0.20

1.6E-36

1.0E-04

−0.15

3.6E-36

1.0E-04

mRNA synthesis rate (Gresham)

−0.22

1.6E-50

1.0E-04

−0.17

5.6E-52

1.0E-04

mRNA synthesis rate (Coller)

−0.28

5.5E-68

1.0E-04

−0.21

2.1E-63

1.0E-04

mRNA decay rate (Cramer 1)

0.37

1.3E-133

1.0E-04

0.29

0.0E + 00

1.0E-04

mRNA decay rate (Cramer 2)

0.35

1.2E-109

1.0E-04

0.26

0.0E + 00

1.0E-04

mRNA decay rate (Gresham)

0.25

2.9E-59

1.0E-04

0.19

0.0E + 00

1.0E-04

mRNA decay rate (Coller)

0.17

5.1E-25

1.0E-04

0.13

0.0E + 00

1.0E-04

Protein per mRNA

−0.31

2.9E-70

1.0E-04

−0.24

1.4E-67

1.0E-04

Ribosome occupancy

−0.34

1.2E-120

1.0E-04

−0.25

8.3E-112

1.0E-04

Protein decay rate

0.10

1.7E-08

1.0E-04

0.08

1.4E-08

1.0E-04

ρ

P value

Permutation

P value

τ

P value

Permutation

P value

mRNA synthesis rate (Cramer 1)

−0.23

2.1E-49

1.0E-04

−0.19

3.6E-48

1.0E-04

mRNA synthesis rate (Cramer 2)

−0.22

7.7E-41

1.0E-04

−0.18

6.1E-40

1.0E-04

mRNA synthesis rate (Gresham)

−0.19

1.3E-36

1.0E-04

−0.15

5.5E-36

1.0E-04

mRNA synthesis rate (Coller)

−0.31

3.2E-83

1.0E-04

−0.25

2.4E-79

1.0E-04

mRNA decay rate (Cramer 1)

0.36

6.3E-122

1.0E-04

0.29

0.0E + 00

1.0E-04

mRNA decay rate (Cramer 2)

0.35

1.8E-110

1.0E-04

0.29

0.0E + 00

1.0E-04

mRNA decay rate (Gresham)

0.30

7.8E-88

1.0E-04

0.25

0.0E + 00

1.0E-04

mRNA decay rate (Coller)

0.14

3.2E-17

1.0E-04

0.11

0.0E + 00

1.0E-04

Protein per mRNA

−0.30

1.0E-62

1.0E-04

−0.24

5.2E-60

1.0E-04

Ribosome occupancy

−0.39

2.5E-162

1.0E-04

−0.32

7.5E-150

1.0E-04

Protein decay rate

0.10

3.1E-08

1.0E-04

0.08

3.3E-08

1.0E-04

ρ

P value

Permutation

P value

τ

P value

Permutation

P value

mRNA synthesis rate (Cramer 1)

−0.01

5.1E-01

2.6E-01

−0.06

8.4E-09

1.0E-04

mRNA synthesis rate (Cramer 2)

−0.05

8.7E-04

3.0E-04

−0.08

1.7E-13

1.0E-04

mRNA synthesis rate (Gresham)

−0.04

1.2E-02

5.9E-03

−0.07

3.0E-11

1.0E-04

mRNA synthesis rate (Coller)

−0.02

2.3E-01

1.1E-01

−0.08

7.3E-13

1.0E-04

mRNA decay rate (Cramer 1)

0.14

2.1E-18

1.0E-04

0.15

2.4E-48

1.0E-04

mRNA decay rate (Cramer 2)

0.15

1.2E-20

1.0E-04

0.16

9.8E-49

1.0E-04

mRNA decay rate (Gresham)

0.07

9.0E-06

1.0E-04

0.10

7.9E-22

1.0E-04

mRNA decay rate (Coller)

0.06

2.0E-04

1.0E-04

0.07

6.2E-10

1.0E-04

Protein per mRNA

−0.07

4.9E-05

1.0E-04

−0.11

7.3E-20

1.0E-04

Ribosome occupancy

−0.06

8.8E-05

1.0E-04

−0.11

1.3E-30

1.0E-04

Protein decay rate

−0.01

6.4E-01

3.3E-01

0.02

7.7E-02

6.2E-02

ρ

P value

Permutation

P value

τ

P value

Permutation

P value

mRNA synthesis rate (Cramer 1)

0.00

8.0E-01

4.1E-01

−0.06

5.7E-09

1.0E-04

mRNA synthesis rate (Cramer 2)

−0.05

3.3E-03

1.3E-03

−0.09

1.2E-15

1.0E-04

mRNA synthesis rate (Gresham)

−0.03

5.0E-02

2.7E-02

−0.06

1.3E-09

1.0E-04

mRNA synthesis rate (Coller)

−0.02

1.9E-01

9.6E-02

−0.10

2.6E-18

1.0E-04

mRNA decay rate (Cramer 1)

0.13

2.8E-16

1.0E-04

0.16

1.1E-50

1.0E-04

mRNA decay rate (Cramer 2)

0.14

8.6E-19

1.0E-04

0.17

2.7E-57

1.0E-04

mRNA decay rate (Gresham)

0.07

2.2E-05

1.0E-04

0.12

8.3E-29

1.0E-04

mRNA decay rate (Coller)

0.04

7.5E-03

3.8E-03

0.06

5.9E-08

1.0E-04

Protein per mRNA

−0.07

6.3E-05

1.0E-04

−0.12

3.2E-23

1.0E-04

Ribosome occupancy

−0.06

1.6E-05

2.0E-04

−0.14

3.7E-44

1.0E-04

Protein decay rate

0.00

7.8E-01

3.9E-01

0.02

3.6E-02

5.0E-02