Skip to main content

Table 4 Summary of the largest effect QTL detected for DMI in U.S. Angus, Hereford, and SimAngus beef cattle

From: Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle

DMI

Position (Chr_Mb)

-log10

P-value

Regression Beta

PVE

Proximal/Putative Candidate Gene(s)

Scientific Precedence [reference]; organism; trait

Angus

8_107

6.53

−2.91

0.039

LOC101902746/TNC

[55]; cattle; feed efficiency

11_97

5.81

2.47

0.034

MVB12B/LMX1B

[56]; human; obesity traits

2_63

5.26

−0.74

0.031

TMEM163/MGAT5

[58, 59, 62]; human, mice; diabetes, nutrient sensing

1_106

5.25

0.67

0.031

LOC782622/LOC785220

NA

7_27

4.89

−2.09

0.029

SLC12A2

[11]; cattle; feed efficiency

11_7

4.88

0.89

0.028

IL1R2

[55]; cattle; feed efficiency

17_57

4.72

0.78

0.027

CUX2

[57]; human; diabetes

9_90

4.68

−0.57

0.027

ESR1

[60, 61]; pig, human; feed efficiency, diabetes, obesity

Hereford

3_70

5.56

0.76

0.026

TYW3/CRYZ

[67]; human; insulin resistance

19_55

5.48

0.79

0.026

MGAT5B

[68]; mice; glycosylation

24_41

5.35

−0.98

0.025

RAB12

[69]; mice; cellular nutrient sensing

3_73

5.35

0.98

0.025

NEGR1

[70,71,72]; humans, rats; feed intake, obesity

19_57

5.09

−0.92

0.024

RAB37

[73]; mice; insulin release

10_47

4.81

0.91

0.022

CA12/LACTB

[74, 75]; humans, mice; pH balance, adiposity

SimAngus

14_17

5.68

−1.05

0.019

NDUFB9/RNF139/MTSS1/SQLE

[28, 82,83,84,85]; cattle, human, mice; feed efficiency, diabetes, obesity

21_16

5.36

−0.49

0.018

SV2B

[86, 87] human; insulin secretion and weight loss

3_22

5.01

−0.49

0.016

LOC104971520/CHD1L/LOC788724/FMO5

[88]; mice; obesity and diabetes

26_14

4.70

0.50

0.015

IDE/CYP26A1

[89,90,91]; humans, mice; insulin degradation, diabetes, obesity

15_58

4.50

0.59

0.014

CAPN5/MYO7A

[92, 93]; cattle, chicken; meat tenderness; abdominal fat

6_91

4.49

−0.45

0.014

CXCL1

[94]; mice; diet-induced obesity

2_47

4.39

−0.50

0.014

LYPD6

[55]; cattle; feed efficiency