From: Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle
MMWT | Position (Chr_Mb) | -log10 P-value | Regression Beta | PVE | Proximal/Putative Candidate Gene(s) | Scientific Precedence [reference]; organism; trait |
---|---|---|---|---|---|---|
Angus | 7_24 | 15.88 | 6.86 | 0.046 | ACSL6 | [13, 129]; cattle, rodents; feed efficiency and growth; diabetic myocardial metabolism |
1_98 | 11.45 | 6.08 | 0.032 | MYNN/ACTRT3/LOC104970973/MECOM | ||
7_0 | 11.31 | 6.97 | 0.032 | LOC100300983/LOC100125913/LOC101902704/LOC101902742/FLT4/CNOT6 | ||
20_72 | 9.12 | 4.89 | 0.025 | PDCD6/SLC9A3 | [136, 137]; human and mice, goat; cell membrane repair and apoptosis, diet induced changes in the rumen | |
21_13 | 8.56 | 5.11 | 0.024 | MCTP2 | [138]; human; adiposity and obesity | |
18_18 | 7.90 | 6.54 | 0.022 | CBLN1/C18H16orf78/ZNF423 | [139, 140]; rat, cattle; appetite regulation, feed efficiency and growth | |
1_108 | 7.64 | 5.29 | 0.021 | PPM1L | [132]; mouse; obesity, metabolic syndrome, and growth | |
1_133 | 7.33 | 4.79 | 0.020 | NCK1 | [133]; mouse; glucose tolerance and insulin resistance | |
Hereford | X_113 | 9.50 | 19.66 | 0.046 | MAGEB16/LOC786694 | [141]; rat; diet induced differential expression and potential risk for carcinogenesis |
X_105 | 6.76 | 13.00 | 0.032 | MAOA/MAOB | [142]; human; obesity | |
20_5 | 5.96 | −3.76 | 0.028 | STC2/LOC101903982/ERGIC1/RPL26L1/ATP6V0E1/CREBRF/BNIP1/NKX2-5 | [143, 144]; human, mouse; adiposity and obesity, skeletal muscle development | |
14_6 | 5.44 | 9.24 | 0.025 | LOC104973978/FAM135B/LRP12/DPYS | [11, 145, 146]; cattle, chicken, human; feed efficiency and growth, obesity, growth retardation | |
19_56 | 5.26 | 6.61 | 0.024 | MGAT5B/MFSD11/SRSF2/METTL23/JMJD6 | [68, 147,148,149]; mice, human; glycosylation, interaction with genes differentially expressed in brown adipose, promoting adipogenic differentiation. | |
22_11 | 4.98 | 3.98 | 0.023 | ITGA9 | [54]; cattle; feed efficiency | |
8_2 | 4.63 | −3.87 | 0.021 | LOC101904351/LOC520638/AADAT | ||
26_19 | 4.55 | 6.99 | 0.021 | GOLGA7B/CRTAC1 | [150, 151]; buffalo, mice; dairy traits, lateral olfactory tract formation | |
X_145 | 4.40 | −3.90 | 0.020 | ANOS1 | [152, 153]; human; puberty timing, serum and free testosterone | |
SimAngus | 14_25 | 6.89 | −2.73 | 0.023 | LYN/RPS20/MOS/PLAG1/CHCHD7/SDR16C5/SDR16C6/PENK | [154,155,156]; bovine, human; birthweight and stature, height |
14_24 | 6.61 | 2.61 | 0.022 | LOC104974018/XKR4/TGS1/LYN/RPS20/MOS/PLAG1/CHCHD7/SDR16C5/SDR16C6/PENK | [154,155,156]; bovine, human; birthweight and stature, height | |
17_18 | 5.15 | −1.91 | 0.017 | MAML3 | [157]; pig; downregulated in obese pigs | |
20_5 | 5.13 | 2.39 | 0.016 | STC2/LOC101903982/ERGIC1/RPL26L1/ATP6V0E1/CREBRF/BNIP1/NKX2-5 | [143, 144]; human, mouse; adiposity and obesity, skeletal muscle development | |
X_148 | 5.10 | −2.33 | 0.016 | NLGN4X | [158, 159]; human; sex-biased exon usage, muscle and development pathways | |
4_10 | 4.94 | 5.70 | 0.016 | HEPACAM2 | [160]; human; mitosis | |
28_1 | 4.64 | −1.74 | 0.015 | TAF5L/URB2 | ||
6_39 | 4.63 | 1.88 | 0.015 | LOC101904320/LCORL/NCAPG | [163, 164]; cattle; feed efficiency and growth traits, body frame size | |
14_26 | 4.51 | 2.08 | 0.014 | FAM110B/UBXN2B/NSMAF/TOX | [165]; cattle; Brahman puberty traits | |
13_50 | 4.51 | 1.84 | 0.014 | BMP2/LOC104973806/LOC104973807/LOC101904237/LOC104973808/LOC104973809 | [166]; pig; loin muscle area, body size, and structure traits | |
13_16 | 4.32 | −2.11 | 0.014 | ITIH5/LOC104973716/LOC101903501/SFMBT2 | ||
27_22 | 4.32 | −3.45 | 0.014 | SGCZ | [41]; human; obesity-related traits |