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Table 6 Summary of the largest effect QTL detected for MMWT in U.S. Angus, Hereford, and SimAngus beef cattle

From: Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle

MMWT

Position (Chr_Mb)

-log10

P-value

Regression Beta

PVE

Proximal/Putative Candidate Gene(s)

Scientific Precedence [reference]; organism; trait

Angus

7_24

15.88

6.86

0.046

ACSL6

[13, 129]; cattle, rodents; feed efficiency and growth; diabetic myocardial metabolism

1_98

11.45

6.08

0.032

MYNN/ACTRT3/LOC104970973/MECOM

[130, 131]; human, mice; obesity and diabetes traits

7_0

11.31

6.97

0.032

LOC100300983/LOC100125913/LOC101902704/LOC101902742/FLT4/CNOT6

[134, 135]; human; cell growth

20_72

9.12

4.89

0.025

PDCD6/SLC9A3

[136, 137]; human and mice, goat; cell membrane repair and apoptosis, diet induced changes in the rumen

21_13

8.56

5.11

0.024

MCTP2

[138]; human; adiposity and obesity

18_18

7.90

6.54

0.022

CBLN1/C18H16orf78/ZNF423

[139, 140]; rat, cattle; appetite regulation, feed efficiency and growth

1_108

7.64

5.29

0.021

PPM1L

[132]; mouse; obesity, metabolic syndrome, and growth

1_133

7.33

4.79

0.020

NCK1

[133]; mouse; glucose tolerance and insulin resistance

Hereford

X_113

9.50

19.66

0.046

MAGEB16/LOC786694

[141]; rat; diet induced differential expression and potential risk for carcinogenesis

X_105

6.76

13.00

0.032

MAOA/MAOB

[142]; human; obesity

20_5

5.96

−3.76

0.028

STC2/LOC101903982/ERGIC1/RPL26L1/ATP6V0E1/CREBRF/BNIP1/NKX2-5

[143, 144]; human, mouse; adiposity and obesity, skeletal muscle development

14_6

5.44

9.24

0.025

LOC104973978/FAM135B/LRP12/DPYS

[11, 145, 146]; cattle, chicken, human; feed efficiency and growth, obesity, growth retardation

19_56

5.26

6.61

0.024

MGAT5B/MFSD11/SRSF2/METTL23/JMJD6

[68, 147,148,149]; mice, human; glycosylation, interaction with genes differentially expressed in brown adipose, promoting adipogenic differentiation.

22_11

4.98

3.98

0.023

ITGA9

[54]; cattle; feed efficiency

8_2

4.63

−3.87

0.021

LOC101904351/LOC520638/AADAT

[81, 111]; chicken, seabass; feed efficiency and growth

26_19

4.55

6.99

0.021

GOLGA7B/CRTAC1

[150, 151]; buffalo, mice; dairy traits, lateral olfactory tract formation

X_145

4.40

−3.90

0.020

ANOS1

[152, 153]; human; puberty timing, serum and free testosterone

SimAngus

14_25

6.89

−2.73

0.023

LYN/RPS20/MOS/PLAG1/CHCHD7/SDR16C5/SDR16C6/PENK

[154,155,156]; bovine, human; birthweight and stature, height

14_24

6.61

2.61

0.022

LOC104974018/XKR4/TGS1/LYN/RPS20/MOS/PLAG1/CHCHD7/SDR16C5/SDR16C6/PENK

[154,155,156]; bovine, human; birthweight and stature, height

17_18

5.15

−1.91

0.017

MAML3

[157]; pig; downregulated in obese pigs

20_5

5.13

2.39

0.016

STC2/LOC101903982/ERGIC1/RPL26L1/ATP6V0E1/CREBRF/BNIP1/NKX2-5

[143, 144]; human, mouse; adiposity and obesity, skeletal muscle development

X_148

5.10

−2.33

0.016

NLGN4X

[158, 159]; human; sex-biased exon usage, muscle and development pathways

4_10

4.94

5.70

0.016

HEPACAM2

[160]; human; mitosis

28_1

4.64

−1.74

0.015

TAF5L/URB2

[161, 162]; human; diabetes, fasting insulin levels

6_39

4.63

1.88

0.015

LOC101904320/LCORL/NCAPG

[163, 164]; cattle; feed efficiency and growth traits, body frame size

14_26

4.51

2.08

0.014

FAM110B/UBXN2B/NSMAF/TOX

[165]; cattle; Brahman puberty traits

13_50

4.51

1.84

0.014

BMP2/LOC104973806/LOC104973807/LOC101904237/LOC104973808/LOC104973809

[166]; pig; loin muscle area, body size, and structure traits

13_16

4.32

−2.11

0.014

ITIH5/LOC104973716/LOC101903501/SFMBT2

[167, 168]; human; fasting insulin and BMI

27_22

4.32

−3.45

0.014

SGCZ

[41]; human; obesity-related traits