Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults

Table 1 Components of different elongation related complexes or protein group

Complex^a	Lilli or AFF4	Su(Tpl) or ELL	Cdk9	Other components	References
P-TEFb	-^b	-	+	Cyclin-T, Cyclin-K	[17, 93, 94]
SEC	+	+	+^c	AFF1, AF9, EAF, ENL	[23, 27]
DotCom	-	-	-	AF9, ENL, Dot1	[27, 95]
EAP	+	+	+	AF5q31, AF9, ENL, Dot1	[27, 32, 96]
MLL	+	+	-	AFF1, AF5q31, AF9, ENL	[23, 97,98,99]
LEC	-	+	-	EAF	[24, 33]
AEP	+	-	+	AF5q31, LAF4, ENL	[34]

^aP-TEFb = Positive Transcript Elongation Factor b; SEC = Super Elongation Complex; DotCom = Dot1 Complex; EAP = Elongation Assisting Proteins; MLL = Mixed Lineage Leukemia 1 proteins; LEC = Little Elongation Complex; AEP = AF4 family/ENL family/P-TEFb complex
^b“+” and “-” denote inclusion and exclusion of proteins respectively
^cA few studies regard P-TEFb as an independent component of SEC [27, 100]

ISSN: 1471-2164