Fig. 1

Identification of colon cancer specific modules using WGCNA, and GO enrichment analysis for these modules. a Clustering dendrogram of gene profilers from the testing dataset with 461 stage II or III colon cancer patients. Hierarchical cluster analysis dendrogram used to detect co-expression clusters. Each short vertical line corresponds to a gene, and the branches are expression modules of highly interconnected groups of genes with a colour to indicate its module assignment. A total of 11 modules ranging from 35 to 866 genes in size were identified. b Topological overlap matrix plot. Genes in the rows and columns are sorted by the clustering tree in (a). Clusters correspond to squares along the diagonal. c Bar plot presenting the top biological process enriched in each of the 11 modules. The original significance output from DAVID was transformed into “–log (p-value)” for plotting