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Fig. 4 | BMC Genomics

Fig. 4

From: Transversions have larger regulatory effects than transitions

Fig. 4

Tv’s have greater regulatory effects than Ts’s. a Schematic of POP-STARR experimental design. b Changes in haplotype effect magnitudes due to the presence of a Ts or Tv within a haplotype. Black squares are effects 1.5× of the interquartile range above the upper quartile or below the lower quartile. P-values were calculated using a t test. c Correlation between change in haplotype effect magnitude and the number of Ts/Tv differences between haplotypes. The red line is the regression line. P-values were calculated using a t test. d Correlation between change in haplotype effect magnitude and the number of Ts/Tv differences between haplotypes which overlap DHS centers. The red line is the regression line. P-values were calculated using a t test. e Boxplots of the effect of transitions and transversions on regulatory element activity as measured in Patwardhan et al., [19]. Each plot shows data from a different enhancer. Each plot shows the absolute log2(fold change) in regulatory element activity for every Ts and Tv assayed in that enhancer. P-values are for a one-sided t test from a linear regression model

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