Table 1 Effects of diet on physiological parameters and circulating cytokines
From: Long-lasting effect of obesity on skeletal muscle transcriptome
Parameters | Before WSD (Chow) | After WSD | After CR | WSD vs Chow | WSD vs CR | Chow vs CR |
|---|---|---|---|---|---|---|
Appetite and activity | ||||||
 Caloric intake, % of chow | 99.7 ± 6.4 | 215.4 ± 19.1 | ND | p < 0.01 | ND | ND |
 Activity (count/day) | 28624.7 ± 6842.7 | 33545.2 ± 5650.0 | 26284.0 ± 6794.2 | NS | NS | NS |
Body composition | ||||||
 Weight (kg) | 11.5 ± 0.6 | 15.1 ± 1.1 | 12.5 ± 1.1 | p < 0.01 | p < 0.01 | NS |
 Body fat (g) | 2040.3 ± 357.0 | 5855.4 ± 881.0 | 3934.2 ± 820.7 | p < 0.01 | p < 0.001 | p < 0.05 |
 Lean mass (g) | 9028.2 ± 354.9 | 8793.9 ± 437.7 | 8179.4 ± 443.6 | NS | NS | p < 0.01 |
Glucose homeostasis | ||||||
 AUC glucose (mg/dl) | 6823.1 ± 440.0 | 8751.5 ± 718.5 | 6735.3 ± 538.5 | p < 0.05 | p < 0.05 | NS |
 AUC insulin (mg/dl) | 4750 ± 647.2 | 10404 ± 2078.9 | 7273.6 ± 1869.3 | p < 0.05 | p < 0.05 | NS |
 Fasting glucose (mg/dl) | 63.5 ± 7.2 | 63.6 ± 4.0 | 65.5 ± 2.8 | NS | NS | NS |
 Fasting insulin (mg/dl) | 21.5 ± 7.8 | 58.5 ± 12.2 | 29.5 ± 6.6 | p < 0.01 | p < 0.05 | p < 0.05 |
 HbA1c, percent | 6.02 ± 0.15 | 6.92 ± 0.23 | 6.35 ± 0.19 | p < 0.001 | p < 0.05 | NS |
 HOMA-IR | 4.05 ± 1.86 | 9.7 ± 2.55 | 4.9 ± 1.3 | p < 0.01 | p < 0.05 | NS |
Serum cytokines | ||||||
 IL6, % of chow | 100 ± 0.0 | 68.9 ± 10.0 | 120.2 ± 7.7 | NS | p < 0.01 | NS |
 IL-8, % of chow | 100 ± 0.0 | 73.5 ± 13.2 | 59.6 ± 11.6 | p < 0.001 | NS | p < 0.001 |
 Eotaxin, % of chow | 100 ± 0.0 | 60.7 ± 6.9 | 49.5 ± 3.6 | p < 0.001 | NS | p < 0.001 |
 MIF Analyte, % of chow | 100 ± 0.0 | 212.8 ± 64.4 | 472.9 ± 110.2 | NS | p < 0.05 | p < 0.01 |
PAI-1, ng/ml | 104.2 ± 5.08 | 121.2 ± 4.73 | 125.2 ± 5.33 | p < 0.05 | NS | p < 0.01 |