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Table 2 The effect of CR on WSD-induced gene expression

From: Long-lasting effect of obesity on skeletal muscle transcriptome

Gene symbol Description Log_FC P-Value FDR
POSTN Periostin, osteoblast specific factor 3.18 1.46E-06 0.0025
SMOC1 SPARC related modular calcium binding 1 1.97 1.30E-07 0.0005
MDK Midkine (neurite growth-promoting factor 2) 1.82 1.11E-05 0.02
SFRP2 Secreted frizzled-related protein 2 1.48 2.80E-07 0.0006
AEBP1 AE binding protein 1 1.41 1.00E-06 0.002
PTGFR Prostaglandin F receptor 1.31 2.72E-05 0.03
RRAD Ras-related associated with diabetes −1.57 1.61E-07 0.0005
TNFRSF12A Tumor necrosis factor receptor superfamily 12A −1.71 8.20E-08 0.0005
SERPINE1 Serpin peptidase inhibitor, clade E −2.53 2.20E-05 0.03
CCDC81 Soiled-coil domain containing 81 −2.68 2.43E-08 0.0003
  1. Soleus muscle biopsies were collected longitudinally, before WSD, 6 months after WSD, and 4 months after CR. Tissue samples were subjected to RNA extraction and RNAseq gene expression and bioinformatic analysis as described in “Materials and Methods”. Table shows upregulated and downregulated differentially expressed genes (DEGs) after CR in comparison with WSD (CR/WSD). Bioinformatic analysis was performed using FDR ≤ 0.05. Log_FC (fold change) was calculated as Log (FC, 2)