Label-free quantitative proteomics of Corynebacterium pseudotuberculosis isolates reveals differences between Biovars ovis and equi strains

Silva, Wanderson M.; Folador, Edson L.; Soares, Siomar C.; Souza, Gustavo H. M. F.; Santos, Agenor V.; Sousa, Cassiana S.; Figueiredo, Henrique; Miyoshi, Anderson; Le Loir, Yves; Silva, Artur; Azevedo, Vasco

doi:10.1186/s12864-017-3835-y

Table 1 Differentially regulated proteins between 258_equi and 1002_ovis

From: Label-free quantitative proteomics of Corynebacterium pseudotuberculosis isolates reveals differences between Biovars ovis and equi strains

Accession		Description		258:1002 Log(2)Ratio^(a)
258_equi	1002_ovis	Description	Score	258:1002 Log(2)Ratio^(a)	p_value^(a)
Cellular processes and signaling
Adhesion and motility cell
I3QUW8_CORPS	D9Q5S4_CORP1	Periplasmic zinc binding protein troA	4245,52	-1,32	0
Cell wall/Membrane and Envelope biogenesis
I3QYI6_CORPS	D9Q3G9_CORP1	Phospho N acetylmuramoyl pentapeptide	166,05	1,22	1
I3QZH4_CORPS	D9Q4F8_CORP1	Corynomycolyl transferase	3886,67	-1,45	0
I3R044_CORPS	D9Q526_CORP1	Peptidoglycan recognition proteino	5283,55	−2,06	0
	D9Q4M0_CORP1	Cell wall channel	2220,85	−2,14	0
I3QYK8_CORPS	D9Q3J1_CORP1	Cell wall peptidase NlpC P60 protein	1207,7	−2,78	0
Defense mechanism
I3QW82_CORPS	D9Q743_CORP1	Cold shock protein	6171,9	1,37	1
I3R0B7_CORPS	D9Q597_CORP1	DNA protection during starvation protein	70,504,73	−1,48	0
I3QV66_CORPS	D9Q632_CORP1	Cold shock protein	31,703,46	−2458	0
I3QZX1_CORPS	D9Q4V4_CORP1	Protein GrpE	57,665,59	−2,64	0
I3QZW9_CORPS	D9Q4V2_CORP1	Heat shock protein HspR	929,96	−3,43	0
Intracellular trafficking secretion and vesicular transport
I3QVC7_CORPS	D9Q697_CORP1	ABC type transporter	376,36	2,91	1
I3QZ34_CORPS	D9Q431_CORP1	ABC transporter ATP binding protein	6339,11	1,54	1
I3QZQ5_CORPS	D9Q4N9_CORP1	ABC superfamily ATP binding cassette	25,578,26	−1,38	0
I3R0D8_CORPS	D9Q5B9_CORP1	Oligopeptide transport system permease	705,01	−1,45	0,01
Post-translational modification, protein turnover, chaperones
I3QWY7_CORPS	D9Q7U6_CORP1	Thioredoxin TrxA	1832,12	3,15	1
I3QVC2_CORPS	D9Q692_CORP1	Thiol disulfide isomerase thioredoxin	157,88	1,80	1
I3QXH3_CORPS	D9Q8C5_CORP1	Proteasome accessory factor PafA2	305,06	−1,32	0
I3QZA4_CORPS	D9Q493_CORP1	Glutaredoxin like protein nrdH	3140,61	−1,34	0
I3QUL7_CORPS	D9Q5I3_CORP1	Peptidyl prolyl cis trans isomerase	49,161,11	−1,44	0
I3QWQ3_CORPS	D9Q7L6_CORP1	Ferredoxin	54,332,67	−1,48	0
I3QW91_CORPS	D9Q753_CORP1	Peptidyl prolyl cis trans isomerase	19,736,36	−1,63	0
I3QV23_CORPS	D9Q5Y2_CORP1	Catalase	52,016,22	−1,70	0
I3QUX7_CORPS	D9Q5T5_CORP1	Glyoxalase Bleomycin resistance protein	18,489,51	−1,99	0
I3QVR1_CORPS	D9Q6M3_CORP1	10 kDa chaperonin	90,387,73	−2,78	0
Signal transduction mechanisms
I3QY22_CORPS	D9Q8W9_CORP1	Phosphocarrier protein HPr	38,569,08	−2,92	0
Information storage and processing
DNA Metabolism: replication, recombination and repair
I3QV41_CORPS	D9Q606_CORP1	Metallophosphoesterase	529,63	1,88	1
I3QWM2_CORPS		Exodeoxyribonuclease 7 small subunit	10,725,45	−2,00	0
Transcription: regulation, degradation and RNA processing
I3QX71_CORPS	D9Q817_CORP1	SAM dependent methyltransferase y	397,16	1,25	0,96
I3QWD6_CORPS	D9Q7A0_CORP1	TetR family regulatory protein	5685,08	−1,38	0
I3QXS5_CORPS	D9Q8M5_CORP1	N utilization substance protein B homol	16,977,04	−1,42	0
I3QWH0_CORPS	D9Q7D4_CORP1	Transcriptional regulatory protein PvdS	7456,32	−1,48	0
I3QYU0_CORPS	D9Q3T4_CORP1	Ferric uptake regulatory protein	7805,46	−1,76	0
I3QWK3_CORPS	D9Q7G7_CORP1	Transcription elongation factor GreA	77,246,3	−1,87	0
I3QZJ2_CORPS	D9Q4H4_CORP1	Transcriptional regulator	10,476,01	−1,93	0
I3QUZ7_CORPS	D9Q5V6_CORP1	Nucleoid associated protein ybaB	81,447,09	−3,04	0
I3QUU4_CORPS	D9Q5Q1_CORP1	YaaA protein	25,362,05	−3,14	0
Translation, ribosomal structure and biogenesis
I3R0I2_CORPS	D9Q5F9_CORP1	Ribosomal RNA small subunit methyltrans	395,99	1,29	1
I3QWD9_CORPS	D9Q7A3_CORP1	30S ribosomal protein S14	4756,75	−1,47	0
Metabolism
Amino acid transport and metabolism
	D9Q3B4_CORP1	Glutamate dehydrogenase	1534,86	3,56	1
I3QXI1_CORPS	D9Q8D2_CORP1	Aspartate ammonia lyase	2326,21	1,60	1
I3QWF9_CORPS	D9Q7C4_CORP1	Glycine betaine transporter	136,23	1,21	1
I3QV21_CORPS	D9Q5Y0_CORP1	Aspartate semialdehyde dehydrogenase	8778,47	−1,28	0
I3QWZ5_CORPS	D9Q7V4_CORP1	Cysteine desulfurase	1813,31	−1,31	0
I3QXT1_CORPS	D9Q8N1_CORP1	Chorismate synthase	5341,49	−1,41	0
I3QXI5_CORPS	D9Q8D5_CORP1	Phosphoribosyl ATP pyrophosphatase	25,184,13	−1,90	0
I3QXL8_CORPS	D9Q8G8_CORP1	UPF0237 protein Cp258 1096	16,011,21	−1,96	0
I3QZZ5_CORPS	D9Q4X5_CORP1	Urease subunit beta	4349,97	−2,12	0
Carbohydrate transport and metabolism
I3R0E6_CORPS	D9Q5C6_CORP1	Aldose 1 epimerase	221,55	2,78	1
I3QV93_CORPS	D9Q660_CORP1	Formate acetyltransferase 1	9381,31	2,00	1
I3QZB7_CORPS	D9Q4A5_CORP1	Phosphoglucomutase	359,43	1,77	1
I3QWW1_CORPS	D9Q7S1_CORP1	L lactate permease	103,53	1,38	0,99
	D9Q8W7_CORP1	PTS system fructose specific EIIABC	191,71	1,35	1
I3QY20_CORPS	D9Q8W6_CORP1	1 phosphofructokinase	2879,52	1,32	1
I3R064_CORPS	D9Q545_CORP1	L lactate dehydrogenase	5695,04	1,32	1
I3R051_CORPS	D9Q691_CORP1	Probable phosphoglycerate mutase	2014,4	−1,24	0
	D9Q396_CORP1	PTS system fructose specific IIABC	507,53	−1,25	0
I3QWR8_CORPS	D9Q7N1_CORP1	Sucrose 6 phosphate hydrolase	6075,08	−1,34	0
I3QYN0_CORPS	D9Q3L2_CORP1	Glycine cleavage system H proteino	91,529,52	−1,38	0
I3QWH7_CORPS	D9Q7D8_CORP1	Glyceraldehyde 3 phosphate dehydrogenase	9529,4	−2,68	0
Coenzyme metabolism
	D9Q862_CORP1	ATP dependent dethiobiotin synthetase B	104,92	−1,24	1
I3QUY1_CORPS	D9Q5T9_CORP1	Pyridoxal biosynthesis lyase PdxSo	1029,15	−1,42	0
I3QXF8_CORPS	D9Q8B1_CORP1	Precorrin 8X methyl mutase	34,981,98	−1,77	0
I3QXE1_CORPS	D9Q893_CORP1	Hemolysin related protein	3609,76	1,35	0
Energy metabolism
I3QUS5_CORPS	D9Q5N2_CORP1	NADH dehydrogenase	3257,66	3,14	1
I3QZ12_CORPS	D9Q411_CORP1	Malate dehydrogenase	11,220,59	1,22	1
I3QXN4_CORPS	D9Q8I5_CORP1	Cytochrome oxidase assembly protein	297,19	−1,86	0,09
I3QYB6_CORPS	D9Q3A4_CORP1	Nitrogen regulatory protein P II	16,165,93	−2,29	0
Inorganic Ion Transport and Metabolism
I3R097_CORPS	D9Q575_CORP1	Cation transport protein	882,31	−4,64	1
I3QZG5_CORPS	D9Q4F0_CORP1	Trk system potassium uptake protein trk	2973,22	1,25	1
I3QVU4_CORPS	D9Q6Q3_CORP1	Hemin binding periplasmic protein hmuT	607,64	1,71	1
I3QVT3_CORPS	D9Q6P2_CORP1	Manganese ABC transporter substrate binding	3917,5	1,51	0
Lipid transport and metabolism
I3QUM7_CORPS	D9Q5J0_CORP1	Phospholipase D	25,847,67	3,27	1
I3QZM9_CORPS	D9Q4L5_CORP1	Secretory lipase	1254	3,08	1
Nucleotide metabolism
I3QZR5_CORPS	D9Q4P8_CORP1	Purine phosphoribosyltransferase	227,51	4,45	1
I3QZF7_CORPS	D9Q4E2_CORP1	Phosphoribosylformylglycinamidine synth	978,57	1,45	1
I3QXV6_CORPS	D9Q8Q6_CORP1	Adenine phosphoribosyltransferaseo	907,16	1,44	1
I3QZ07_CORPS	D9Q406_CORP1	Nucleoside diphosphate kinase	14,996,33	1,35	1
I3QZG8_CORPS	D9Q4F3_CORP1	HIT family protein	4039,81	1,21	1
Secondary metabolites biosynthesis, transport and catabolism
I3QWA4_CORPS	D9Q766_CORP1	Multidrug resistance protein norMo	208,76	1,35	0,98
Poorly characterized
General function prediction only
I3QXE6_CORPS	D9Q898_CORP1	Methyltransferase type 11	102,29	2,84	0,99
I3QWH3_CORPS	D9Q7D6_CORP1	Enoyl CoA hydratase	225,9	2,14	1
	D9Q5M7_CORP1	Unknown function	2201,88	1,93	1
I3QZJ7_CORPS	D9Q4I2_CORP1	Carbonic anhydrase	550,46	1,81	1
I3QWR6_CORPS	D9Q7M9_CORP1	Unknown function	246,05	1,24	0,98
I3QX38_CORPS		Cutinase	11,245,11	−1,48	0
I3QXY3_CORPS	D9Q8T2_CORP1	Chlorite dismutase	32,986,51	−1,51	0
I3QW56_CORPS	D9Q720_CORP1	Methylmalonyl CoA carboxyltransferase 1	4283,03	−1,52	0
I3QWE6_CORPS	D9Q7B0_CORP1	Serine protease	5615,41	−1,54	0
I3QX14_CORPS	D9Q7X2_CORP1	Aldo keto reductase	6121,73	−1,63	0
I3QWR9_CORPS	D9Q7N2_CORP1	Alpha acetolactate decarboxylase	1839,59	−1,73	0
I3QUU3_CORPS	D9Q5Q0_CORP1	UPF0145 protein Cp258 0101	3922,57	−1,77	0
I3QV73_CORPS	D9Q639_CORP1	Hydrolase domain containing protein	5759,37	−2,23	0
I3QZM7_CORPS	D9Q4L2_CORP1	Rhodanese related sulfurtransferase	7428,74	−2,46	0
I3QYY9_CORPS	D9Q3Y7_CORP1	Ankyrin domain containing proteino	11,948,84	−2,84	0
I3QW24_CORPS	D9Q6Y4_CORP1	Hydrolase domain containing protein	15,589,93	−3,04	0
Unknown function
I3R0H3_CORPS	D9Q5F1_CORP1	Unknown function	7862,73	3,59	1
I3QX01_CORPS	D9Q7W0_CORP1	Unknown function	276,68	3,43	1
I3QYP3_CORPS	D9Q3P0_CORP1	Unknown function	1609,29	2,84	1
I3QWZ8_CORPS	D9Q7V7_CORP1	Unknown function	1476,56	2,58	1
I3R0H2_CORPS	D9Q5F0_CORP1	Unknown function	572,19	1,90	1
I3QY71_CORPS	D9Q919_CORP1	Unknown function	1466,6	1,78	1
I3QWL3_CORPS	D9Q7H7_CORP1	Unknown function	304,96	1,65	0,98
I3QUW1_CORPS	D9Q5R7_CORP1	Unknown function	504,13	1,60	1
I3QYF2_CORPS	D9Q3D7_CORP1	Unknown function	985,97	1,47	1
I3QWR5_CORPS	D9Q7M8_CORP1	Unknown function	103,03	1,45	1
I3QVG0_CORPS	D9Q6C8_CORP1	Unknown function	4085,83	1,39	1
I3QXI8_CORPS	D9Q8D8_CORP1	Unknown function	87,929,25	−1,35	0
I3QVZ1_CORPS	D9Q6U7_CORP1	Unknown function	64,404,7	−1,38	0
I3R094_CORPS	D9Q572_CORP1	Unknown function	4367,05	−1,68	0
I3QYW4_CORPS	D9Q3V8_CORP1	Unknown function	15,928,9	−1,96	0
I3QUX9_CORPS	D9Q5T7_CORP1	Unknown function	8100,51	−2,00	0
I3QYG8_CORPS	D9Q3F3_CORP1	Unknown function	78,035,52	−2,09	0
I3QUZ5_CORPS	D9Q5V4_CORP1	Unknown function	77,763,68	−2,09	0
I3QUR3_CORPS	D9Q5M1_CORP1	Unknown function	12,731,48	−2,27	0
I3QVV7_CORPS	D9Q6R6_CORP1	Unknown function	8564,11	−3,47	0
I3QXX0_CORPS	D9Q8S0_CORP1	Unknown function	19,485,3	−3,50	0
I3QW02_CORPS	D9Q6W1_CORP1	Unknown function	49,581,23	−3,76	0
I3QVS0_CORPS	D9Q6N1_CORP1	Unknown function	66,162,63	−4,87	0
I3R0G5_CORPS	D9Q5E4_CORP1	Unknown function	39,265,48	−5,65	0

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