Table 3 Pathway enrichment analysis of up-regulated pathways in swiftlet salivary glands
AA versus Aerodramus species | Number of pathways up-regulated | Top 3 regulated pathway |
|---|---|---|
AA | 328 | - Translation factors (27.4%) |
- mRNA processing (10.9%) | ||
- Spliceosome (8.8%) | ||
Aerodramus species | 341 | - mRNA processing (15.5%) |
- Protein export (14.4%) | ||
- Squamous cell TarBase (9.1%) | ||
AFC versus AMC | Number of pathways up-regulated | Top 3 regulated pathway |
AFC | 152 | - PI3K-Akt signaling pathway (46%) |
- Ribosome biogenesis in eukaryotes (12.5%) | ||
- Cardiac muscle contraction (6.5%) | ||
AMC | 120 | - Ras signalling pathway (38%) |
- MAPK signalling pathway (29%) | ||
- Proteasome (20%) | ||
AFM versus AFC | Number of pathways up-regulated | Top 3 regulated pathway |
AFM | 34 | - Galactose metabolism (38%) |
- Endocytosis (15%) | ||
- Oxidative phosphorylation (15%) | ||
AFC | 7 | - Mitochondrial fatty acid oxidation (43%) |
- RNA transport (29%) | ||
- Proteoglycan (29%) | ||
Gender comparison | ||
AFC | Number of pathways up-regulated | Top 3 regulated pathway |
Female | 34 | -DNA repair (61%) |
-Circadian clock (20%) | ||
-Cell cycle (12%) | ||
Male | 25 | -Mitochondrial protein (40%) |
-Peptide hormone metabolism (23%) | ||
-Muscle contraction (15%) | ||
AFM | Number of pathways up-regulated | Top 3 regulated pathway |
Female | 0 | -NA |
Male | 15 | -Transmembrane transport of small molecule (17.5%) |
-Protein metabolism (5.8%) | ||
-Signal transduction (5.1%) | ||
AMC | Number of pathways up-regulated | Top 3 regulated pathway |
Female | 13 | -Organelle biogenesis and maintenance (23%) |
-Muscle contraction (17%) | ||
-Axon guidance (9%) | ||
Male | 5 | -Vesicle-mediated transport (38%) |
-Extracellular matrix transport (29%) | ||
-Signal transduction (23%) | ||