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Table 3 Pathway enrichment analysis of up-regulated pathways in swiftlet salivary glands

From: De novo transcriptome analysis shows differential expression of genes in salivary glands of edible bird’s nest producing swiftlets

AA versus Aerodramus species Number of pathways up-regulated Top 3 regulated pathway
AA 328 - Translation factors (27.4%)
- mRNA processing (10.9%)
- Spliceosome (8.8%)
Aerodramus species 341 - mRNA processing (15.5%)
- Protein export (14.4%)
- Squamous cell TarBase (9.1%)
AFC versus AMC Number of pathways up-regulated Top 3 regulated pathway
AFC 152 - PI3K-Akt signaling pathway (46%)
- Ribosome biogenesis in eukaryotes (12.5%)
- Cardiac muscle contraction (6.5%)
AMC 120 - Ras signalling pathway (38%)
- MAPK signalling pathway (29%)
- Proteasome (20%)
AFM versus AFC Number of pathways up-regulated Top 3 regulated pathway
AFM 34 - Galactose metabolism (38%)
- Endocytosis (15%)
- Oxidative phosphorylation (15%)
AFC 7 - Mitochondrial fatty acid oxidation (43%)
- RNA transport (29%)
- Proteoglycan (29%)
Gender comparison
AFC Number of pathways up-regulated Top 3 regulated pathway
Female 34 -DNA repair (61%)
-Circadian clock (20%)
-Cell cycle (12%)
Male 25 -Mitochondrial protein (40%)
-Peptide hormone metabolism (23%)
-Muscle contraction (15%)
AFM Number of pathways up-regulated Top 3 regulated pathway
Female 0 -NA
Male 15 -Transmembrane transport of small molecule (17.5%)
-Protein metabolism (5.8%)
-Signal transduction (5.1%)
AMC Number of pathways up-regulated Top 3 regulated pathway
Female 13 -Organelle biogenesis and maintenance (23%)
-Muscle contraction (17%)
-Axon guidance (9%)
Male 5 -Vesicle-mediated transport (38%)
-Extracellular matrix transport (29%)
-Signal transduction (23%)
  1. AFC Aerodramus fuciphagus from cave
  2. AFM Aerodramus fuciphagus from man-made house
  3. AMC Aerodramus maximus from cave
  4. AA Apus affinis
  5. NA No regulated pathways with p-value <0.05 was identified