Genome-wide analysis of DNA methylation in hypothalamus and ovary of Capra hircus

BMC Genomics

Table 3 Correlation between DMGs and DEGs

	Hypothalamus	Obs. DMGs	Obs. DEGs	DEGs ∩ DMGs	100 k simulation of ∩	±SD	P-value
Positive Correlation	Hyper DMGs/over DEGs	455	1138	34	30.46	5.25	0.318
Positive Correlation	Hypo DMGs/under DEGs	1263	1583	42	103.44	9.38	1.97E-10
Negative Correlation	Hyper DMGs/under DEGs	455	1583	49	34.89	5.60	0.0167
Negative Correlation	Hypo DMGs/over DEGs	1263	1138	231	99.10	9.11	1.29E-46

Hypo and hyper-methylated genes (FDR < 0.05) overlapping with under and overexpressed genes (FDR < 0.001) in the hypothalamus (DEGs ∩ DMGs). A jackknife simulation test with relative P-values (observed vs random expectation) was performed for each subgroup

ISSN: 1471-2164