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Fig. 6 | BMC Genomics

Fig. 6

From: Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

Fig. 6

Potential miRNA:mRNA Interactions at Baseline: In-silico analysis of potential miRNA:mRNA interactions in the Nrf2 ablated myocardium. Given that the vast majority of mRNA expression changes occurred in the form of downregulation, bioinformatic predictions were made for upregulated miRNAs. To account for the varied computational aspects of commonly employed prediction tools, associations were made using the following 6 algorithms: miRANDA-mirSVR, TargetScan, MirTarget2 (miRDB), DIANA-microT-CDS, rna22, and PITA. A total of 39 downregulated DEGs contained potential miRNA recognition elements for the following upregulated miRNAs; miR-30b-5p, miR-350-3p, miR-582-5p, and miR-208a-5p. These miRNAs may synergistically regulate gene expression in knockout mice as 22 DEGs were shared by 2 or more miRNAs. 5 DEGs were shared by 3 upregulated miRNAs and an additional 5 DEGs harbored potential recognition elements for all 4 miRNAs

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