Table 5 Essential reactions unique to resistant parasites

CO2tmt

CO₂[m] < => CO₂[c]

-

CO₂ transport

-

EX_folate4

p-aminobenzoate[e] < =>

-

p-aminobenzoate exchange

-

EX_fru(e)

fructose[e] < =>

-

fructose exchange

-

EX_thm(e)

thiamine[e] < =>

-

thiamine exchange

-

FRUt1r

fructose[e] < => fructose[c]

-

fructose transport

PFB0210c

FUM_mt

fumarate [m] + H₂O[m] < => malate[m]

4.2.1.2

fumarate hydratase in the TCA cycle

PFI1340w

FUMtmt

fumarate[m] < => fumarate [c]

-

fumarate transport into mitochondria

-

GHMT2r

serine[c] + thf[c] < => glyine[c] + H₂O[c] + mthf[c]

2.1.2.1

serine hydroxymethyltransferase in folate synthesis

PFL1720w

GLYCL_mt

glycine[m] + NAD[m] + thf[m] < => CO₂[m] + mlthf[m] + NADH[m] + NH₄[m]

many

glycine cleavage system in folate synthesis and amino acid metabolism

PF13_0345^a

PFL1550w

MAL13P1.390

PF14_0497

PF11_0339

GLYtmt

glycine[m] < => glycine[c]

-

glycine transport into mitochondria

-

HEX7

ATP[c] + fructose[c] = > ADP[c] + fructose-6-phosphate[c] + h[c]

2.7.1.1

hexokinase of glycolysis

PFF1155w

MDHm

malate[m] + NAD[m] < => h[m] + NADH[m] + oxaloacetate[m]

1.1.1.37

malate dehydrogenase in the TCA Cycle

PFF0895w

MLTHFtmt

mthf[m] < => mthf[c]

-

mthf transport into mitochondria

MAL8P1_13*

PF11_0172

NADPHtmt

NADPH[c] < => NADPH[m]

-

NADPH transport into mitochondria

-

NADPtmt

NADPc] < => NADP[m]

-

NADP transport into mitochondria

-

NH4tmt

NH₄[m] < => NH₄[c]

-

NH₄ transport into mitochondria

-

OAAtmt

oxaloacetate [m] < => oxaloacetate[c]

-

oxaloacetate into mitochondria

-

THFtmt

thf[m] < => thf[c]

-

thf into mitochondria

-

THMt3

h[c] + thiamine[e] < => h[e] + thiamine[c]

-

thiamine import

-

TMDPK

ATP[c] + thiamine[c] = > AMP[c] + h[c] + thiamine diphosphate[c]

2.7.6.2

thiamine diphosphokinase in cofactor metabolism

PFI1195c

pABAt

p-aminobenzoate[e] < => p-aminobenzoate[c]

-

p-aminobenzoate import

MAL8P1_13^a PF11_0172