Table 2 Features shared by genes involved in the same heterogeneous or polygenic diseases

Total number

621

25,100

2576

 In same cytogenetic band

136 (21.9%)

326 (1.3%)

335 (13.0%)

 In tandem repeat

51 (8.2%)

58 (0.2%)

92 (3.6%)

 In TF/target pairs

39 (6.3%)

81 (0.3%)

94 (3.6%)

 Co-regulated by the same TF (not involved in the disease)

273 (44.0%)

2308 (9.2%)

626 (24.3%)

 Sharing MF GO

586 (94.4%)

19,075 (76.0%)

2369 (92.0%)

 Sharing BP GO

597 (96.1%)

22,948 (91.4%)

2502 (97.1%)

 Sharing CC GO

604 (97.3%)

23,645 (94.2%)

2519 (97.8%)

 Sharing KEGG pathway

349 (56.2%)

3129 (12.5%)

1074 (41.7%)

 Sharing REACTOME pathway

474 (76.3%)

9806 (39.1%)

1554 (60.3%)

 Interacting in PDB

96 (15.5%)

207 (0.8%)

199 (7.7%)

 In the same CORUM complex

86 (13.8%)

469 (1.9%)

225 (8.7%)

 In the same CENSUS complex

45 (7.2%)

166 (0.7%)

119 (4.6%)

 Directly linked in STRING

291 (46.9%)

1535 (6.1%)

932 (36.2%)

 Indirectly linked in STRING

115 (18.5%)

4355 (17.4%)

1346 (52.3%)

 Directly linked in BIOGRID (physical interaction)

250 (40.3%)

944 (3.8%)

799 (31.0%)

 Indirectly linked in BIOGRID (physical interaction)

160 (25.8%)

5228 (20.8%)

1607 (62.4%)

 Directly linked in BIOGRID (genetic interaction)

9 (1.4%)

13 (0.1%)

19 (0.7%)

 Indirectly linked in BIOGRID (genetic interaction)

25 (4.0%)

45 (0.2%)

62 (2.4%)