Table 2 Predicted effect on Ebola virus VP24-KPNA5 complex stability by mutation of residues that are differentially conserved in Reston in Ebola VP24
From: Investigating Ebola virus pathogenicity using molecular dynamics
Mutation | mCSM stability (ΔΔG - Kcal/mol) | mCSM PP affinity (ΔΔG - Kcal/mol) | FoldX stability (ΔΔG - Kcal/mol) |
|---|---|---|---|
T131S | −1.29 | −0.32 | −0.42 |
N132 T | −0.62 | −2.65 | −1.22 |
M136 L | −0.81 | 0.17 | 0.18 |
Q139R | −1.06 | −0.99 | 1.59 |
T131S,M136 L,Q139R | NA | NA | −0.3 |