Fig. 5

Comparison of average urine levels of amino acids between the different severity score groups, for individuals with b(o+)AT mutations. There is one plot per prediction method (PolyPhen2, SIFT Mutation Assessor, and FATHMM). The group numbers are given at the bottom of the plots, with the sample number given in brackets underneath the group name. Where significant differences between groups occur (p < 0.05) the p-value is displayed on the plot, e.g. (1–2)p = 0.001 means a significant difference between groups 1 and 2